Anne van der Geest, Annemarieke van Opstal, Saskia van Hemert, Linda van de Burgwal
{"title":"肠道细菌和ASS:对现状的探索","authors":"Anne van der Geest, Annemarieke van Opstal, Saskia van Hemert, Linda van de Burgwal","doi":"10.36254/wta.2022.2.04","DOIUrl":null,"url":null,"abstract":"Th rough the gut-brain axis, there is communication between cognitive, emotional and behavioral brain centers on one side and the gut on the other. Disruption of the composition of gut bacteria can potentially cause the gut-brain axis to malfunction, leading to behavioral and gut problems linked to Autism Spectrum Disorders (ASD). Examples of interventions that potentially have an influence on the composition of gut bacteria include diet, poop transplants and probiotics. Th e restricted diet of patients with ASD may explain the disruption of the composition of gut bacteria. However, this does not appear to be a cause of ASD but the disturbance may be causing (worsening) of the symptoms. Another intervention that can aff ect the gut microbiota is a poop transplant. Improvement on several symptoms, such as social skills, hyperactivity, stereotyped behavior, and speech was observed, but the lack of a control group limits the validity of these results. A third type of intervention aimed at influencing the gut microbiota is probiotics. Although it is plausible that probiotics have an eff ect on ASD, this has not yet been scientifi cally established. This is because such research is inherently complex due to the large diversity of possible probiotics, the heterogeneity in the microbiota itself, external influences that are difficult to control, the range and heterogeneity in ASD symptoms, and the amount of factors that contribute to the development of ASD symptoms. In practice, it is difficult to establish “one size fi ts all” guidelines. Hence, working with an individualized approach that tailors interventions to each individual’s unique profile is recommended. For health care providers, this can be an opportunity to focus on what works in the specific situation of my patient.","PeriodicalId":283749,"journal":{"name":"Wetenschappelijk Tijdschrift Autisme","volume":"64 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Darmbacteriën en ASS: een verkenning van de stand van zaken\",\"authors\":\"Anne van der Geest, Annemarieke van Opstal, Saskia van Hemert, Linda van de Burgwal\",\"doi\":\"10.36254/wta.2022.2.04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Th rough the gut-brain axis, there is communication between cognitive, emotional and behavioral brain centers on one side and the gut on the other. Disruption of the composition of gut bacteria can potentially cause the gut-brain axis to malfunction, leading to behavioral and gut problems linked to Autism Spectrum Disorders (ASD). Examples of interventions that potentially have an influence on the composition of gut bacteria include diet, poop transplants and probiotics. Th e restricted diet of patients with ASD may explain the disruption of the composition of gut bacteria. However, this does not appear to be a cause of ASD but the disturbance may be causing (worsening) of the symptoms. Another intervention that can aff ect the gut microbiota is a poop transplant. Improvement on several symptoms, such as social skills, hyperactivity, stereotyped behavior, and speech was observed, but the lack of a control group limits the validity of these results. A third type of intervention aimed at influencing the gut microbiota is probiotics. Although it is plausible that probiotics have an eff ect on ASD, this has not yet been scientifi cally established. This is because such research is inherently complex due to the large diversity of possible probiotics, the heterogeneity in the microbiota itself, external influences that are difficult to control, the range and heterogeneity in ASD symptoms, and the amount of factors that contribute to the development of ASD symptoms. In practice, it is difficult to establish “one size fi ts all” guidelines. Hence, working with an individualized approach that tailors interventions to each individual’s unique profile is recommended. 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Darmbacteriën en ASS: een verkenning van de stand van zaken
Th rough the gut-brain axis, there is communication between cognitive, emotional and behavioral brain centers on one side and the gut on the other. Disruption of the composition of gut bacteria can potentially cause the gut-brain axis to malfunction, leading to behavioral and gut problems linked to Autism Spectrum Disorders (ASD). Examples of interventions that potentially have an influence on the composition of gut bacteria include diet, poop transplants and probiotics. Th e restricted diet of patients with ASD may explain the disruption of the composition of gut bacteria. However, this does not appear to be a cause of ASD but the disturbance may be causing (worsening) of the symptoms. Another intervention that can aff ect the gut microbiota is a poop transplant. Improvement on several symptoms, such as social skills, hyperactivity, stereotyped behavior, and speech was observed, but the lack of a control group limits the validity of these results. A third type of intervention aimed at influencing the gut microbiota is probiotics. Although it is plausible that probiotics have an eff ect on ASD, this has not yet been scientifi cally established. This is because such research is inherently complex due to the large diversity of possible probiotics, the heterogeneity in the microbiota itself, external influences that are difficult to control, the range and heterogeneity in ASD symptoms, and the amount of factors that contribute to the development of ASD symptoms. In practice, it is difficult to establish “one size fi ts all” guidelines. Hence, working with an individualized approach that tailors interventions to each individual’s unique profile is recommended. For health care providers, this can be an opportunity to focus on what works in the specific situation of my patient.