{"title":"选择性激发神经元的光学系统","authors":"Alex D. Johnstone, Bo Fu, Noah A. Russell","doi":"10.1109/FOI.2011.6154849","DOIUrl":null,"url":null,"abstract":"When studying activity in neuronal networks it is desirable to induce arbitrary patterns of action potential activity. Neurons transduced with light-sensitive ion channels (ChR2 and NpHR) can be stimulated by incident light. Prior research has determined that irradiance of at least 1mWmm−2 pulsed at 1kHz at 470nm (for excitation) and 590nm (for inhibition) will result in reliable stimulation of a neuron.","PeriodicalId":240419,"journal":{"name":"2011 Functional Optical Imaging","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Optical system for selectively firing neurons\",\"authors\":\"Alex D. Johnstone, Bo Fu, Noah A. Russell\",\"doi\":\"10.1109/FOI.2011.6154849\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"When studying activity in neuronal networks it is desirable to induce arbitrary patterns of action potential activity. Neurons transduced with light-sensitive ion channels (ChR2 and NpHR) can be stimulated by incident light. Prior research has determined that irradiance of at least 1mWmm−2 pulsed at 1kHz at 470nm (for excitation) and 590nm (for inhibition) will result in reliable stimulation of a neuron.\",\"PeriodicalId\":240419,\"journal\":{\"name\":\"2011 Functional Optical Imaging\",\"volume\":\"28 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2011 Functional Optical Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/FOI.2011.6154849\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2011 Functional Optical Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/FOI.2011.6154849","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
When studying activity in neuronal networks it is desirable to induce arbitrary patterns of action potential activity. Neurons transduced with light-sensitive ion channels (ChR2 and NpHR) can be stimulated by incident light. Prior research has determined that irradiance of at least 1mWmm−2 pulsed at 1kHz at 470nm (for excitation) and 590nm (for inhibition) will result in reliable stimulation of a neuron.
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