社区获得的肺炎短期治疗优于传统治疗:RCT检测结果

Gruppo di lettura di Parma
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引用次数: 0

摘要

这项方法学质量良好的美国多中心研究采用创新方法,在抗生素治疗的第三天入组了380例无并发症的社区获得性肺炎(CAP)病例,首次证明了6-71个月儿童短期抗生素治疗(5天)优于传统治疗。作者用来评估优劣的RADAR评分不仅考虑了对治疗的临床反应和症状的缓解,还考虑了抗生素治疗不良反应的存在和严重程度(方框1)。在每种策略中,临床反应不足的儿童略低于10%。与标准治疗相比,短时间治疗有69%的概率(95% CI, 63-75)呈现出更理想的RADAR评分。此外,作者还对171名儿童进行了抗生素耐药性(耐药瘤)基因分析。短时间治疗显著降低了每个原核细胞(RGPC)的平均耐药基因数,有助于对抗抗生素耐药的问题现象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
La terapia breve per la polmonite acquisita in comunità è superiore alla terapia tradizionale: i risultati del RCT SCOUT-CAP
Brief therapy for community-acquired pneumonia is superior to traditional therapy: findings from SCOUT-CAP RCT This US multicenter study of good methodological quality, with an innovative method of enrollment of 380 uncomplicated cases of community-acquired pneumonia (CAP) on the third day of antibiotic therapy, is the first one to demonstrate the superiority a short antibiotic therapy (5 days) in children aged 6-71 months compared to the traditional one. The RADAR score used by the authors to assess superiority considers not only the clinical response to therapy and resolution of symptoms but also the presence and severity of adverse effects of antibiotic therapy (box.1). Slightly less than 10% of children in each strategy have an inadequate clinical response. Short therapy has a 69% probability (95% CI, 63-75) of presenting a more desirable RADAR score than standard therapy. In addition, the authors performed antibiotic resistance (resistoma) gene analysis for a group of 171 children. The average number of antibiotic resistance genes per prokaryotic cell (RGPC) was significantly lower with short therapy and thus helpful in counteracting the problematic phenomenon of antibiotic resistance.
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