CX3CL1-CX3CR1轴、C3、C4和ESR抗体在伊拉克SLE患者致病性中的作用

Sumer 1 Pub Date : 2023-08-15 DOI:10.21931/rb/css/s2023.08.01.21

Mohammed Amer Kamil, Hazima Mossa Alabassi, Zahraa Hussein M. Kadr

{"title":"CX3CL1-CX3CR1轴、C3、C4和ESR抗体在伊拉克SLE患者致病性中的作用","authors":"Mohammed Amer Kamil, Hazima Mossa Alabassi, Zahraa Hussein M. Kadr","doi":"10.21931/rb/css/s2023.08.01.21","DOIUrl":null,"url":null,"abstract":"Background: Systematic Lupus erythematosus (SLE) has been described as a\nchronic inflammatory illness where chemokines play an essential role in its\npathogenesis CX3CL1and CX3CR1 are chemokines that described their crucial\nrole in immune response in SLE patients. Aim of the study: To evaluate the serum\nlevel of CX3CL1- CX3CR1, C3, C4 & ESR Abs in SLE patients without treatment\nand compare their level with those under treatment (hydroxychloroquine,predeslone 5-20mg, D3). Patients collecting and Methods: 120 females with\nSLE and healthy, with ages ranging between 20-40 years, were involved in this\ninvestigation from Medical City (Consultant of Arthritis, Consultant of Dermatology, Lobby of Hematology and Arthritis)/ Baghdad Teaching Hospital and from\nAl-Imameen Al-Kazimeen Teaching Hospital from August 26 to October 18,\n2021. The samples included 80females with SLE (40 females as early diagnosed\npatients (G2) without treatment, 40 females as patients that received treatment\nsubjects (hydroxychloroquine, predeslone 5-20mg, D3) (G3), while the control\ngroup included 40 healthy females (G1). Five mL of venous blood were obtained\nfrom patients and healthy females for measuring C3, C4, ESR and serum levels of\nCX3CL1 and CX3CR1, which were measured using the ELISA method. Results:\nOur findings demonstrated a significant increase in the serum levels of CX3CL1,\nCX3CR1, and ESR. Also, there were significant decreases in serum levels of C3\nand C4 in SLE patients (with and without treatment) compared to the control\ngroup, and a significant difference was detected between SLE patients without\ntreatment and patients receiving treatment. Conclusion: Based on our results,\nCX3CL1 and CX3CR1 chemokines may have a role in the pathogenesis of SLE as\nthey are increased in SLE patients. In addition, serum CX3CL1 levels can be used\nas an independent biomarker of SLE activity. Furthermore, low levels of c3 and c4\nand high levels of ESR are considered diagnostic indicators of SLE disease in\npeople.\nKeywords: Systemic lupus erythematosus, CX3CL1; CX3CR1. C3,C4","PeriodicalId":443152,"journal":{"name":"Sumer 1","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of CX3CL1-CX3CR1 Axis, C3, C4 & ESR Abs in pathogenicity of Iraqi patients with SLE\",\"authors\":\"Mohammed Amer Kamil, Hazima Mossa Alabassi, Zahraa Hussein M. Kadr\",\"doi\":\"10.21931/rb/css/s2023.08.01.21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Systematic Lupus erythematosus (SLE) has been described as a\\nchronic inflammatory illness where chemokines play an essential role in its\\npathogenesis CX3CL1and CX3CR1 are chemokines that described their crucial\\nrole in immune response in SLE patients. Aim of the study: To evaluate the serum\\nlevel of CX3CL1- CX3CR1, C3, C4 & ESR Abs in SLE patients without treatment\\nand compare their level with those under treatment (hydroxychloroquine,predeslone 5-20mg, D3). Patients collecting and Methods: 120 females with\\nSLE and healthy, with ages ranging between 20-40 years, were involved in this\\ninvestigation from Medical City (Consultant of Arthritis, Consultant of Dermatology, Lobby of Hematology and Arthritis)/ Baghdad Teaching Hospital and from\\nAl-Imameen Al-Kazimeen Teaching Hospital from August 26 to October 18,\\n2021. The samples included 80females with SLE (40 females as early diagnosed\\npatients (G2) without treatment, 40 females as patients that received treatment\\nsubjects (hydroxychloroquine, predeslone 5-20mg, D3) (G3), while the control\\ngroup included 40 healthy females (G1). Five mL of venous blood were obtained\\nfrom patients and healthy females for measuring C3, C4, ESR and serum levels of\\nCX3CL1 and CX3CR1, which were measured using the ELISA method. Results:\\nOur findings demonstrated a significant increase in the serum levels of CX3CL1,\\nCX3CR1, and ESR. Also, there were significant decreases in serum levels of C3\\nand C4 in SLE patients (with and without treatment) compared to the control\\ngroup, and a significant difference was detected between SLE patients without\\ntreatment and patients receiving treatment. Conclusion: Based on our results,\\nCX3CL1 and CX3CR1 chemokines may have a role in the pathogenesis of SLE as\\nthey are increased in SLE patients. In addition, serum CX3CL1 levels can be used\\nas an independent biomarker of SLE activity. Furthermore, low levels of c3 and c4\\nand high levels of ESR are considered diagnostic indicators of SLE disease in\\npeople.\\nKeywords: Systemic lupus erythematosus, CX3CL1; CX3CR1. C3,C4\",\"PeriodicalId\":443152,\"journal\":{\"name\":\"Sumer 1\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sumer 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/s2023.08.01.21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sumer 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/s2023.08.01.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景:系统性红斑狼疮(SLE)被认为是一种慢性炎症性疾病，趋化因子在其发病过程中起重要作用。cx3cl1和CX3CR1是趋化因子，在SLE患者的免疫应答中起关键作用。研究目的:评价未接受治疗的SLE患者血清CX3CL1- CX3CR1、C3、C4和ESR抗体水平，并与接受治疗(羟氯喹、前体龙5-20mg、D3)的患者进行比较。患者收集和方法:本研究于2021年8月26日至10月18日在Medical City(关节炎顾问，皮肤病学顾问，血液和关节炎大厅)/巴格达教学医院和al - imameen Al-Kazimeen教学医院进行，年龄在20-40岁之间，120名健康的女性sle患者。样本包括80例女性SLE患者(40例为未治疗的早期诊断患者(G2)， 40例为接受治疗的女性(羟氯喹，泼地龙5-20mg, D3) (G3)，对照组40例为健康女性(G1)。取患者及健康女性静脉血5 mL，测定C3、C4、ESR及血清cx3cl1、CX3CR1水平，采用ELISA法测定。结果:我们的研究结果显示血清CX3CL1、CX3CR1和ESR水平显著升高。此外，与对照组相比，SLE患者(治疗前后)血清中c3和C4水平显著降低，且未治疗与接受治疗的SLE患者血清中c3和C4水平存在显著差异。结论:基于我们的研究结果，CX3CL1和CX3CR1趋化因子在SLE患者中升高，可能在SLE的发病机制中发挥作用。此外，血清CX3CL1水平可作为SLE活动性的独立生物标志物。此外，低水平的c3和c4和高水平的ESR被认为是SLE疾病的诊断指标。关键词:系统性红斑狼疮;CX3CL1;CX3CR1。C3, C4

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Role of CX3CL1-CX3CR1 Axis, C3, C4 & ESR Abs in pathogenicity of Iraqi patients with SLE

Background: Systematic Lupus erythematosus (SLE) has been described as a chronic inflammatory illness where chemokines play an essential role in its pathogenesis CX3CL1and CX3CR1 are chemokines that described their crucial role in immune response in SLE patients. Aim of the study: To evaluate the serum level of CX3CL1- CX3CR1, C3, C4 & ESR Abs in SLE patients without treatment and compare their level with those under treatment (hydroxychloroquine,predeslone 5-20mg, D3). Patients collecting and Methods: 120 females with SLE and healthy, with ages ranging between 20-40 years, were involved in this investigation from Medical City (Consultant of Arthritis, Consultant of Dermatology, Lobby of Hematology and Arthritis)/ Baghdad Teaching Hospital and from Al-Imameen Al-Kazimeen Teaching Hospital from August 26 to October 18, 2021. The samples included 80females with SLE (40 females as early diagnosed patients (G2) without treatment, 40 females as patients that received treatment subjects (hydroxychloroquine, predeslone 5-20mg, D3) (G3), while the control group included 40 healthy females (G1). Five mL of venous blood were obtained from patients and healthy females for measuring C3, C4, ESR and serum levels of CX3CL1 and CX3CR1, which were measured using the ELISA method. Results: Our findings demonstrated a significant increase in the serum levels of CX3CL1, CX3CR1, and ESR. Also, there were significant decreases in serum levels of C3 and C4 in SLE patients (with and without treatment) compared to the control group, and a significant difference was detected between SLE patients without treatment and patients receiving treatment. Conclusion: Based on our results, CX3CL1 and CX3CR1 chemokines may have a role in the pathogenesis of SLE as they are increased in SLE patients. In addition, serum CX3CL1 levels can be used as an independent biomarker of SLE activity. Furthermore, low levels of c3 and c4 and high levels of ESR are considered diagnostic indicators of SLE disease in people. Keywords: Systemic lupus erythematosus, CX3CL1; CX3CR1. C3,C4

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Sumer 1

自引率

0.00%

发文量