WaterMap originates in dehydron-based drug design

Copyright: © 2017 Fernández A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Drug-based targeted therapy demands skillful and subtle molecular design. The ease with which water may be locally removed from around the target protein provides a striking blueprint that steers the design process. To that effect, local de-wetting propensities have been mapped on the aqueous interface of the target proteins. These maps have served as precursors to WaterMap, now the gold standard in the field.