格林-巴罗综合征综述

S. Esmail
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引用次数: 1

摘要

吉兰-巴罗综合征(GBS)是一种急性自身免疫性多神经根神经病变,在世界范围内具有很高的患者发病率和死亡率。在临床、电生理和生化水平上的表现是高度异质性的,这意味着最好将GBS概念化为一系列疾病,而不是单一的疾病。尽管表现多样,但GBS的管理相对刻板,尽管以临床严重程度为指导。治疗主要局限于一般的支持措施,静脉注射免疫球蛋白(IVIG)和血浆置换(PLEX),目前在临床实践中口服或静脉注射皮质类固醇没有作用。一些经过验证的预后评分系统可以预测长期残障的可能性,可能有助于针对高危患者群体进行强化治疗。本文的目的是提供GBS的实际概述,特别强调临床表现,调查和管理这一重要的神经系统疾病的频谱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Guillain-Barré Syndrome
Guillain-Barré Syndrome (GBS) is an acute, autoimmune polyradiculoneuropathy that carries great patient morbidity, and significant mortality, worldwide. The manifestations are highly heterogeneous at the clinical, electrophysiological and biochemical levels, which means that it is better to conceptualise GBS as a spectrum of disorders rather than a singular one. Despite the diverse range of presentations, the management of GBS is relatively stereotyped, albeit guided by the level of clinical severity. Treatment is largely restricted to general supportive measures, Intravenous Immunoglobulin (IVIG) and Plasma Exchange (PLEX), with no current role for oral or intravenous corticosteroids in clinical practice. Several validated prognostic-scoring systems, which can predict the probability of long-term residual disability, may assist in targeting intensive therapies to high-risk patient groups. The aim of this article is to provide a practical overview of GBS, with particular emphasis on the clinical presentation, investigation and management of this important spectrum of neurological conditions.
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