Poorly Differantiated Rectal Cancer With Breast Metastases

Objective: Rectal cancer can rarely metastasize to breast. It is an indicator of widespread stage and poor prognosis. We aim to present a rectum cancer patient who developed breast metastasis. Case: A 48-year-old female patient, underwented abdominoperitoneal resection operation due to obstruction. She was diagnosed with Stage-IIIC poorly differentiated rectal adenocarcinoma. Multiple metastasis were detected in the fourth month of adjuvant therapy. The patient was diagnosed with rectal cancer that had metastasized to the breast and soft tissue. FOLFIRI-Aflibercept treatment was started for MSI-stable, KRAS mutant and BRAF wild, metastatic rectal carcinoma. Progression detected after three cycles of treatment. Patient was died nine month after diagnosis. Conclusion: The breast is an unexpected site of metastasis for non-mammary solid tumors. Taking a biopsy from every metastatic lesion and detailed evaluation are important.