The practice of microbiological monitoring of the dynamics antibiotics resistance for Infection prevention and control program

In the last decade, there has been a sharp increase in the prevalence of various types of antimicrobial resistant bacteria, including enterobacteria, resistant to carbapenems and multiresistant strains of Acinetobacter baumanii and Pseudomonas aeruginosa, S. аureus resistant to betalactam antibiotics and glycopeptides. The aim of the study was to assess the prevalence of multidrug-resistant microorganisms in healthcare organizations in Minsk. To compare the structure and resistance of microorganisms, the data obtained in the study of isolates isolated from the blood of patients from anesthesiology and resuscitation departments of children's hospitals of health organizations for the adult population of Minsk in 2015–2017 were analyzed. It has been established that the structure of the main clinically significant microorganisms isolated from the blood samples of adult patients has differences from the microorganisms isolated from the blood of children's hospitals patients. Significant differences in the level of antibiotic resistance of isolates isolated from patients in pediatric hospitals and hospitals for adults have been established. Thus, the level of antibiotic resistance of Acinetobacter baumannii isolates to ampicillin / sulbactam, ceftazidime, cefepime, ciprofloxacin is higher in adult healthcare organizations than in healthcare organizations for children, while the level of resistant isolates to gentamicin is higher (p < 0,05). Resistance was high for all tested antimicrobials. It has been shown that the level of antibiotic resistance of isolates from samples from adult patients is higher compared to that in the children's hospitals. A significant difference was found in the level of resistance of Klebsiella pneumoniae ss. pneumoniae to ampicillin, ceftazidime, gentamicin (p < 0,05). The level of resistant isolates of Staphylococcus aureus ss. aureus, from blood samples from patients in adult hospitals, to oxacillin, gentamicin, levofloxacin, erythromycin is higher compared to that in the pediatric patients.