The Sensitivity and Specificity of Saliva Biomarker MMP-9 for Detection Oral Squamous Cell Carcinoma (OSCC)

Within the past 10 years, the application of saliva as a diagnostic tool has gained considerable attention and well-accepted method. As a diagnostic fluid, saliva offers superiority over serum due to both noninvasive collection methods and a cost-effective approach for screening of large populations. In addition, collection of saliva offers a reduced risk of infection compared to the serum sampling (1). Early detection of disease plays a significant role in successful treatment. In most cases of various diseases, early diagnosis leads to a greater survival rate with a reduced chance of the disease recurrence. Successful monitoring of a disease, especially in its early stage, may also reduce any severe impacts on a patient’s health or help to prevent and/or delay succeeding complications. Following disease progression, and monitor post-treatment therapeutic effect through a noninvasive method is one of the primary objectives in the field of healthcare research. Saliva, a multi-constituent oral fluid that can be collected through noninvasive methods, has considerable potential Abstract