Quality of Life, Anxiety, Depression and Psychological Distress in Patients with Cancer During the COVID 19 Pandemic: A Systematic Review

Introduction and Objectives: Quality of life (QOL) and psychological wellbeing deteriorate during the COVID 19 pandemic in patients with cancer. Purpose: This study aims to review the current evidence of QOL, anxiety, depression, psychological distress, and their inter-relationship in patients with cancer and survivors during the COVID 19 pandemic. Moreover, this study identifies factors associated with QOL and mental health in patients with cancer and survivors during the COVID 19 pandemic. Methods: An extensive electronic database search was conducted. Articles published in English assessing cancer patients and cancer survivors’ QOL and psychological wellbeing. Results: Twenty-seven articles with 22,134 participants were included. Concerns related to contracting COVID 19, along with potential treatment plans were predictors of impaired QOL. Advanced age, family support, being identified as a male and having less comorbid conditions were associated with the high level of QOL. Delay or change in treatment plan, contact with COVID 19 positive individuals, and emotional vulnerability were found to be independently associated with high levels of anxiety, depression, and distress. Conclusion: Health professionals, caregivers and support services should pay more attention on QOL and psychological wellbeing of the patients with cancer. Counselling sessions, support services should be established to improve their life satisfaction and wellbeing.