肌瘤与不孕症

Juan Luis Giraldo Moreno, Susana Salazar López
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摘要

子宫肌瘤(也称为平滑肌瘤或肌瘤)是最常见的盆腔肿瘤,影响超过70%的70岁以上的女性,尽管大多数女性没有症状,但一些女性可能会出现症状,这取决于它们的位置和大小,这可能会改变你的生活质量,如子宫异常出血、贫血、盆腔疼痛和压力、性交困难、尿频增加和便秘。它与不孕症的关系一直存在争议,尽管对浆膜下肌瘤不明显,但扭曲子宫内膜腔的粘膜下和壁内肌瘤似乎会影响胚胎着床,并与早期妊娠丢失的风险增加有关。它的治疗将取决于病人的症状、大小、位置、是一个还是多个,以及她是否患有不孕症。很明显,粘膜下肌瘤对生育能力有负面影响,而对于壁内肌瘤,已知大于4厘米的肌瘤会改变怀孕的可能性,但有研究表明,即使是较小的或多个肌瘤也会影响怀孕率。治疗肌瘤有多种选择;然而,孕妇、内科或外科治疗的患者应该个体化,特别是如果他们要接受手术治疗,建议在手术干预前对肌瘤进行良好的测绘。微创手术仍然是首选的入路,在腹腔镜手术禁忌或多发性肌瘤患者应保留开放入路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fibroids and Infertility
Uterine fibroids (also known as leiomyomas or myomas) are the most common pelvic tumors, affecting more than 70% of women over 70 years of age and although most are asymptomatic, some women may experience symptoms, depending on their location and size, which can alter your quality of life, such as abnormal uterine bleeding, anemia, pelvic pain and pressure, dyspareunia, increased urinary frequency and constipation. Its relationship with infertility has been controversial and, although insignificant for subserous fibroids, it appears that submucosal and intramural fibroids that distort the endometrial cavity can affect embryo implantation and are associated with an increased risk of early pregnancy loss. Its treatment will depend on the patient’s symptoms, size, location, whether it is one or multiple, and whether or not she suffers from infertility. It is clear that submucosal fibroids have a negative impact on fertility and with respect to intramural fibroids it is known that fibroids larger than 4 cm alter the probability of pregnancy, however there are studies that show that even smaller or multiple fibroids could affect pregnancy rates. There are multiple options for the treatment of fibroids; however, patients who are candidates for expectant, medical or surgical management should be individualized, and especially if they are going to be taken to surgery, an excellent mapping of fibroids prior to surgical intervention is recommended. Minimally invasive surgery continues to be the approach of choice, it should be left for the open approach in cases in which Laparoscopy is contraindicated or the patient with multiple myomatosis.
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