Infertility and Assisted Reproduction [Working Title]最新文献

Effect of Heavy Metals on Tyrosine Kinases Signaling during Sperm Capacitation 重金属对精子获能过程中酪氨酸激酶信号传导的影响

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-09-01 DOI: 10.5772/intechopen.99261

Bhawna Kushwaha, R. Beniwal, Aradhana Mohanty, Ajay K. Singh, R. Yadav, S. K. Garg

引用次数: 1

Understanding Male Infertility for Promising ART 了解男性不育为有前途的ART

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-08-31 DOI: 10.5772/intechopen.98504

M. Zargar, Faisel Ahmad, M. Lateef, T. M. Malla

{"title":"Understanding Male Infertility for Promising ART","authors":"M. Zargar, Faisel Ahmad, M. Lateef, T. M. Malla","doi":"10.5772/intechopen.98504","DOIUrl":"https://doi.org/10.5772/intechopen.98504","url":null,"abstract":"Infertility is a serious problem of not being able to conceive despite regular intercourse for more than a year. Natural conception is seen to be achieved in 80%–85% of couples. About 15% of couples suffer infertility with male factor contributing to almost 50% of cases. Paradoxically, on traditional assessment, the underlying etiology of male contribution towards infertility remains unrecognized in 30% of the patients and thereby grouped as idiopathic. Diagnostics of male infertility cannot therefore be limited to usual semen analysis only. The spectrum of the recent research encourages the experts in the field to approach the Clinical, Molecular and cytogenetic shades associated with the problem besides secondary factors like life style and environment. Clinical assessment sums the medical history and physical examination of the affected individual. Molecular and cytogenetic analysis help gain new insights in understanding the problem and thereby an advantage for a successful assisted reproductive treatment (ART). Given the cost and burden ART puts in and prior to application of any invasive techniques, understanding precisely the etiology associated with male infertility is essential for the fertility specialist to circumvent inefficient or any unproductive steps in the fertilization process besides helping in counseling patients on their chance of success with the use of reproductive technology.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116490135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

You Have a New Super Power: Ethics of oocyte Cryopreservation 你有了一种新的超能力:卵母细胞冷冻保存的伦理学

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-07-29 DOI: 10.5772/intechopen.98392

L. Mohammadi, Silvia Martinez, D. Aranda

引用次数: 0

Fibroids and Infertility 肌瘤与不孕症

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-07-06 DOI: 10.5772/INTECHOPEN.98402

Juan Luis Giraldo Moreno, Susana Salazar López

{"title":"Fibroids and Infertility","authors":"Juan Luis Giraldo Moreno, Susana Salazar López","doi":"10.5772/INTECHOPEN.98402","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.98402","url":null,"abstract":"Uterine fibroids (also known as leiomyomas or myomas) are the most common pelvic tumors, affecting more than 70% of women over 70 years of age and although most are asymptomatic, some women may experience symptoms, depending on their location and size, which can alter your quality of life, such as abnormal uterine bleeding, anemia, pelvic pain and pressure, dyspareunia, increased urinary frequency and constipation. Its relationship with infertility has been controversial and, although insignificant for subserous fibroids, it appears that submucosal and intramural fibroids that distort the endometrial cavity can affect embryo implantation and are associated with an increased risk of early pregnancy loss. Its treatment will depend on the patient’s symptoms, size, location, whether it is one or multiple, and whether or not she suffers from infertility. It is clear that submucosal fibroids have a negative impact on fertility and with respect to intramural fibroids it is known that fibroids larger than 4 cm alter the probability of pregnancy, however there are studies that show that even smaller or multiple fibroids could affect pregnancy rates. There are multiple options for the treatment of fibroids; however, patients who are candidates for expectant, medical or surgical management should be individualized, and especially if they are going to be taken to surgery, an excellent mapping of fibroids prior to surgical intervention is recommended. Minimally invasive surgery continues to be the approach of choice, it should be left for the open approach in cases in which Laparoscopy is contraindicated or the patient with multiple myomatosis.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"25 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125616679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficiency of Autologous Egg Cryopreservation: Eight Years’ Experiences and Clinical Outcomes 自体卵子冷冻保存的有效性:8年的经验和临床结果

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-06-25 DOI: 10.5772/intechopen.98675

Cassie T. Wang, Xiangli Niu, Qiuyan Ruan, Weihua Wang

{"title":"Efficiency of Autologous Egg Cryopreservation: Eight Years’ Experiences and Clinical Outcomes","authors":"Cassie T. Wang, Xiangli Niu, Qiuyan Ruan, Weihua Wang","doi":"10.5772/intechopen.98675","DOIUrl":"https://doi.org/10.5772/intechopen.98675","url":null,"abstract":"Oocyte cryopreservation is one of the state-of-art technologies in human reproductive medicine, which brings opportunities for women to preserve their fertility. In the present study, we analyzed the efficiency and outcomes of 8 years’ autologous egg cryopreservation: Frozen oocytes were warmed from 120 cycles and oocyte survival, fertilization, blastocyst development, clinical pregnancy, embryo implantation, live birth rates and birth weights were collected based on the patients’ ages of <35, 35–37 and > 37 years old. The details of oocyte cryopreservation and the efficiency were further analyzed based on different patient categories. During the study period, 849 oocytes from 120 cycles were warmed. Oocyte survival, fertilization, and blastocyst development were not affected by women’s ages at the time of cryopreservation. However, number of patients without blastocyst formation was significantly (P < 0.05) higher in patients >37 years old (31.2%) than that in patients <35 years old (13.1%). Higher live birth rates were observed in patients <35 (51.1%) and 35–37 (46.7%) years old than in patients >37 years old (28.6%) after fresh embryo transfer. Some patients did not have blastocysts mainly due to low fertilization by poor sperm or small number of oocytes warmed. These results indicate that the efficiency of oocyte cryopreservation, evaluated by live birth and embryo implantation rates is affected by women’s age, number of oocytes warmed and sperm quality.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126310839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial Receptivity in Patients with Polycystic Ovary Syndrome 多囊卵巢综合征患者的子宫内膜容受性

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-06-24 DOI: 10.5772/intechopen.98624

A. Albu, D. Albu

引用次数: 0

A Method for Small Number of Human Sperm Cryopreservation 一种少量人精子冷冻保存方法

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-06-22 DOI: 10.5772/intechopen.98674

Xiangli Niu, Huang Hua, Yi Mo, Yan Sun, Weihua Wang

{"title":"A Method for Small Number of Human Sperm Cryopreservation","authors":"Xiangli Niu, Huang Hua, Yi Mo, Yan Sun, Weihua Wang","doi":"10.5772/intechopen.98674","DOIUrl":"https://doi.org/10.5772/intechopen.98674","url":null,"abstract":"Recently, some sperm vitrification devices were developed to simplify the procedures to freeze small number of human sperm. In the present study, we used these devices to further examine some factors that affect sperm motility after fast freezing. Experiments were designed to examine the effects of 1) direct immersion of the devices to liquid nitrogen and indirect immersion of the devices to liquid nitrogen in which the devices were sealed in cryogenic storage vials; 2) different freezing volumes (1–5 μl); 3) different equilibration times (1–5 min); and 4) different ratio of freezing solution (0,1-5,1) on post thawing sperm motility. It was found that fast sperm freezing in the sealed vials had high post thawing sperm motility (91.3–93.7% of recovered sperm motility rates) while direct immersion of the devices to liquid nitrogen had 0% post thawing sperm motility. No differences in the recovered sperm motility rates were observed between different freezing solution volumes (87.4–90.5%), different equilibration times (89.5–94.0%), and different freezing solution ratios (90.8–94.6%). However, only 6.8% of recovered sperm motility rate was obtained if sperm were frozen in the medium without sperm freezing solution. These results indicate that human sperm can be rapidly frozen after the devices are sealed in the vials with different equilibration time in the medium containing sperm freezing solution. High post thawing sperm motility can be recovered with this method so that ~90% of sperm are usable after freezing.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121738706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recurrent Implantation Failure: The Role of Anatomical Causes 反复植入失败:解剖原因的作用

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-06-11 DOI: 10.5772/intechopen.98505

Mariana Fonseca Roller Barcelos, Aluísio Mendes da Rocha Filho, A. E. Goulart, A. L. M. Souza, Daniely T. Costa, G. F. Barros, Isa Theodoro, J. P. B. Brasileiro, Murilo Cezar Souza Oliveira, N. Z. Tierno, T. Q. F. Ribeiro, V. L. M. Castro, V. Lopes

{"title":"Recurrent Implantation Failure: The Role of Anatomical Causes","authors":"Mariana Fonseca Roller Barcelos, Aluísio Mendes da Rocha Filho, A. E. Goulart, A. L. M. Souza, Daniely T. Costa, G. F. Barros, Isa Theodoro, J. P. B. Brasileiro, Murilo Cezar Souza Oliveira, N. Z. Tierno, T. Q. F. Ribeiro, V. L. M. Castro, V. Lopes","doi":"10.5772/intechopen.98505","DOIUrl":"https://doi.org/10.5772/intechopen.98505","url":null,"abstract":"Recurrent implantation failure (RIF) is one of the great challenges of current reproductive medicine. The term refers to the failure of repeated transfers of embryos of good morphological quality. Embryo implantation is a crucial moment in in vitro fertilization (IVF) treatments. A successful pregnancy depends on a synchronized interaction between a good quality embryo and a receptive endometrium. Its failure may be a consequence of embryo quality, anatomical or immunological factors. The anatomic causes constitute an important factor for RIF, although they are usually manageable. Fibroids, polyps and adhesions that develop after a surgical procedure or infection can hamper the embryo - endometrium attachment process. In addition, Mullerian abnormalities and hydrosalpinx can cause a negative impact on implantation rates and should also be taken into account in patients with RIF. In this chapter, we will address the main anatomical causes that may impact the implantation rates of patients undergoing IVF, as well as recommendations on management and its treatment.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126046238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reasons and Mechanisms of Recurrent Failed Implantation in IVF IVF中反复着床失败的原因和机制

Infertility and Assisted Reproduction [Working Title] Pub Date : 2021-06-07 DOI: 10.5772/INTECHOPEN.98301

V. Fodina, A. Dudorova, J. Ērenpreiss

引用次数: 1

Effects of Different Types of Incubators on Embryo Development and Clinical Outcomes 不同类型培养箱对胚胎发育及临床结局的影响

Infertility and Assisted Reproduction [Working Title] Pub Date : 2020-12-09 DOI: 10.21203/rs.3.rs-122464/v1

Ji Liu, Yanhua Zhou, Xiao-Xiao Wang, Lingkun Tong, Yan-hong Li, Ling Liu, Zhiyan Xu, Honghui Wang

{"title":"Effects of Different Types of Incubators on Embryo Development and Clinical Outcomes","authors":"Ji Liu, Yanhua Zhou, Xiao-Xiao Wang, Lingkun Tong, Yan-hong Li, Ling Liu, Zhiyan Xu, Honghui Wang","doi":"10.21203/rs.3.rs-122464/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-122464/v1","url":null,"abstract":"Main differences of incubators are humidity, temperature and gas control ways, which play important roles in regulating the steady state of culture media. In this study, we compared the effects of different types of incubators (air jacket incubators and water jacket incubators) on embryo development and clinical outcomes in human assisted reproduction. We found that temperature recovery time in air jacket incubators was significantly shorter than that in water jacket incubators. Although the O2 recovering time was also significantly shorter in air jacket incubators as compared with the water jacket incubator, no significant differences were observed in CO2 recovering time between two groups, which was also verified by pH recovering time of culture media. Besides, the temperature of culture medium in the dish covered with oil recovered more quickly in the air jacket incubators. However, there were no significant differences observed in the fertilization rate, Day 3 high-quality embryo rate, blastocyst rate, good blastocyst rate and clinical outcomes between two groups. These results indicate that the microenvironment, especially the temperature, in air jacket incubator recover faster than that in water jacket incubators, however, there were no significant differences in embryo development and clinical outcomes between two types of incubators.","PeriodicalId":415770,"journal":{"name":"Infertility and Assisted Reproduction [Working Title]","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128259802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0