肿瘤血管的同步辐射小视场血管造影

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Pub Date : 2001-10-25 DOI:10.1109/IEMBS.2001.1017254

K. Umetani, T. Yamashita, N. Maehara, S. Imai, Y. Kajihara

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引用次数: 0

摘要

利用SPring-8的第三代同步辐射源和高分辨率检测器，在兔癌模型中进行了分辨率约为10 /spl mu/m的微血管造影，以描绘血管生成血管。在同步辐射摄影中，较长的源到目标的距离和较小的源点可以产生高分辨率的图像。VX2癌移植于兔耳廓。利用该成像系统，在耳动脉注射造影剂后，可见血管生成的未成熟血管网络中直径为20-30 /spl mu/m的小肿瘤血管。

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Small-field angiographic imaging of tumor blood vessels using synchrotron radiation

Microangiography with about 10 /spl mu/m resolution has been carried out for depicting angiogenic vessels in a rabbit model of cancer using a high-resolution detector and a third generation synchrotron radiation source at SPring-8. In synchrotron radiation radiography, a long source-to-object distance and a small source spot can produce high-resolution images. VX2 carcinoma had been transplanted in a rabbit auricle. By using this imaging system, small tumor blood vessels with diameters of 20-30 /spl mu/m in an immature vascular network produced by angiogenesis were visualized after contrast material injection to the auricular artery.

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2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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