{"title":"eIF3A和eIF4E在卵巢癌中的表达及其与预后的关系","authors":"Guo Yuanli","doi":"10.52152/spr/2022.163","DOIUrl":null,"url":null,"abstract":"To investigate the role of eIF3A and eIF4E in ovarian cancer and their relationship with prognosis. The differential expression of eIF3A and eIF4 genes in ovarian cancer tissues and cells was analyzed by Gene Expression Omnibus (GEO). The target genes of eIF3A and eIF4 were searched by Cytoscape in STRING database. The relationship between eIF3A and eIF4E and prognosis was analyzed by TCGA database. The expression of eIF3A and eIF4E in ovarian cancer was verified by immunohistochemistry. The expressions of eIF3A and eIF4E were detected in ovarian cancer tissues, and compared with normal tissues, the expressions of eIF3A and eIF4E were higher in OC tissues, and the difference was statistically significant compared with the para-cancer group (P<0.05). Immunohistochemical results of clinical samples further verified this conclusion. TCGA database analysis showed that the expression of eIF3A and eIF4E was related to the median survival time of patients, and ENO was found to be the downstream target gene of eIF4.The expressions of eIF3a and eIF4E are closely related to the occurrence, development and poor prognosis of ovarian cancer, and they are expected to become unique molecular markers for clinical diagnosis, treatment and prognosis of ovarian cancer.","PeriodicalId":162349,"journal":{"name":"Science Progress and Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of eIF3A and eIF4E in ovarian cancer and its relationship with prognosis\",\"authors\":\"Guo Yuanli\",\"doi\":\"10.52152/spr/2022.163\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To investigate the role of eIF3A and eIF4E in ovarian cancer and their relationship with prognosis. The differential expression of eIF3A and eIF4 genes in ovarian cancer tissues and cells was analyzed by Gene Expression Omnibus (GEO). The target genes of eIF3A and eIF4 were searched by Cytoscape in STRING database. The relationship between eIF3A and eIF4E and prognosis was analyzed by TCGA database. The expression of eIF3A and eIF4E in ovarian cancer was verified by immunohistochemistry. The expressions of eIF3A and eIF4E were detected in ovarian cancer tissues, and compared with normal tissues, the expressions of eIF3A and eIF4E were higher in OC tissues, and the difference was statistically significant compared with the para-cancer group (P<0.05). Immunohistochemical results of clinical samples further verified this conclusion. TCGA database analysis showed that the expression of eIF3A and eIF4E was related to the median survival time of patients, and ENO was found to be the downstream target gene of eIF4.The expressions of eIF3a and eIF4E are closely related to the occurrence, development and poor prognosis of ovarian cancer, and they are expected to become unique molecular markers for clinical diagnosis, treatment and prognosis of ovarian cancer.\",\"PeriodicalId\":162349,\"journal\":{\"name\":\"Science Progress and Research\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science Progress and Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52152/spr/2022.163\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Progress and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52152/spr/2022.163","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
探讨eIF3A和eIF4E在卵巢癌中的作用及其与预后的关系。应用Gene expression Omnibus (GEO)分析eIF3A和eIF4基因在卵巢癌组织和细胞中的差异表达。利用Cytoscape在STRING数据库中检索eIF3A和eIF4的靶基因。采用TCGA数据库分析eIF3A和eIF4E与预后的关系。免疫组化检测eIF3A和eIF4E在卵巢癌组织中的表达。在卵巢癌组织中检测到eIF3A、eIF4E的表达，与正常组织相比，卵巢癌组织中eIF3A、eIF4E的表达较高，与癌旁组比较，差异有统计学意义(P<0.05)。临床标本的免疫组化结果进一步证实了这一结论。TCGA数据库分析显示，eIF3A和eIF4E的表达与患者的中位生存时间有关，并发现ENO是eIF4的下游靶基因。eIF3a和eIF4E的表达与卵巢癌的发生、发展和不良预后密切相关，有望成为卵巢癌临床诊断、治疗和预后的独特分子标志物。
Expression of eIF3A and eIF4E in ovarian cancer and its relationship with prognosis
To investigate the role of eIF3A and eIF4E in ovarian cancer and their relationship with prognosis. The differential expression of eIF3A and eIF4 genes in ovarian cancer tissues and cells was analyzed by Gene Expression Omnibus (GEO). The target genes of eIF3A and eIF4 were searched by Cytoscape in STRING database. The relationship between eIF3A and eIF4E and prognosis was analyzed by TCGA database. The expression of eIF3A and eIF4E in ovarian cancer was verified by immunohistochemistry. The expressions of eIF3A and eIF4E were detected in ovarian cancer tissues, and compared with normal tissues, the expressions of eIF3A and eIF4E were higher in OC tissues, and the difference was statistically significant compared with the para-cancer group (P<0.05). Immunohistochemical results of clinical samples further verified this conclusion. TCGA database analysis showed that the expression of eIF3A and eIF4E was related to the median survival time of patients, and ENO was found to be the downstream target gene of eIF4.The expressions of eIF3a and eIF4E are closely related to the occurrence, development and poor prognosis of ovarian cancer, and they are expected to become unique molecular markers for clinical diagnosis, treatment and prognosis of ovarian cancer.
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