[阿尔茨海默病中乙酰胆碱酯酶的组织化学表征]。

Acta histochemica. Supplementband Pub Date : 1992-01-01
J Ulrich
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引用次数: 0

摘要

大脑新皮层、内嗅皮层和海马中的老年斑对乙酰胆碱酯酶(AChE)有反应。与β蛋白的免疫染色一样,观察到相同类型的斑块,包括非常简单的斑块,几乎完全由松散的β蛋白沉积物组成。如果有很多斑块,正常的ache阳性轴突网络就会消失。一方面,乙酰胆碱酯酶从轴突向斑块的明显转移,另一方面,乙酰胆碱酯酶阳性沉积在斑块形成过程中的早期发展,这两者的解释都在寻求之中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Histochemical representation of acetylcholinesterase in Alzheimer's disease].

Senile plaques in the cerebral neocortex, entorhinal cortex and hippocampus are reactive for Acetylcholinesterase (AChE). The same types of plaques are observed, as with immunostains for beta-protein, including the very simple ones, consisting nearly exclusively of loose deposits of beta-protein. If there are many plaques, the normal network of AChE-positive axons disappears. Explanations for both, the apparent shift of AChE from the axons to the plaques on the one hand and the very early development of AChE positive deposits during the plaque development on the other hand are sought.

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