用于卵母细胞操作的磁改良软微致动器

Y. Yamanishi, S. Sakuma, F. Aral
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引用次数: 25

摘要

我们开发了一种新型的磁性驱动聚合物微工具,用于芯片上的非侵入性和无污染实验。该复合材料是通过将磁铁矿颗粒悬浮在聚二甲基硅氧烷中形成的。为了获得精密复杂的磁性微刀具图案,利用厚KMPR-1050光刻胶作为牺牲模,采用光刻技术。这些工具的新奇之处在于:1。2.任意二维形状的制作;柔软,3。无触点驱动,4。批量生产,成本低。这些多功能磁性微工具可应用于搅拌器,阀门,装载机和分选机等各种功能。这项技术的潜在影响包括样品选择和分离,颗粒装载和固定,遗传操作,跟踪,混合和反应技术到便携式微流控芯片实验室,培养系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Magnetically Modified Soft Micro Actuators for Oocyte Manipulation
We have developed novel magnetically driven polymeric microtool for non-intrusive and no contamination experiments on a chip. The composite is formed by suspending magnetite particles in polydimethylsiloxane. In order to obtain precise and complicated pattern of magnetic microtools, a photolithography techniques has been applied by making good use of thick KMPR-1050 photoresist as sacrifice-mold. The novelties of these tools are 1. fabrication of any 2D shape, 2.softness, 3. no contact actuation, 4. mass production with low cost. These versatile magnetic mirotools can be applied to various functions such as stirrer, valve, loader and sorter and so on. The potential impact of this technology includes sample selection and separation, particle loading and immobilization, genetic operation, tracking, mixing and reaction techniques into portable microfluidic labs-on-a-chip, culture systems.
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