COVID -19后患者的霉菌研究:来自三级医疗中心的经验

N. Gade
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摘要

导言:2019冠状病毒病(COVID-19)大流行已成为本世纪的全球卫生危机,给人类造成了沉重的生命代价。第二波COVID-19对患者来说是致命的,因为他们必须与病毒以及由它引发的机会性真菌和细菌感染作斗争。毛霉病因其在第二波COVID-19期间的广泛存在而受到关注。材料与方法:对鼻窦活检组织、深鼻拭子、支气管肺泡灌洗液、痰液等临床标本进行KOH检查和Sabouraud’s葡萄糖琼脂培养,研究真菌元素的存在。通过生长特性、LPCB湿载和玻片培养对分离真菌进行鉴定。结果:研究期间共收到214份样品,其中真菌生长阳性17份(7.9%)。分离最多的是阿根霉。在COVID-19住院期间,糖尿病和类固醇的使用被认为是常见的危险因素。鼻-脑毛霉菌病是最常见的类型。结论:侵袭性霉菌感染如不及时发现,可导致致命后果。真菌的准确鉴定对于适当的抗真菌治疗是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of Molds in Post COVID -19 Patients: An experience from Tertiary Care Centre
Introduction: Coronavirus disease 2019 (COVID-19) pandemic has emerged as a global health crisis in the century with a heavy toll on human life. The second wave of COVID-19 was lethal for the patients as they had to combat the virus along with the opportunistic fungal and bacterial infections triggered by it. Mucormycosis gained attention for its widespread existence during this period of the second wave of COVID-19. Material & Methods: Various clinical samples like biopsy tissues from paranasal sinuses, deep nasal swabs, bronchoalveolar lavage, sputum, etc. were studied for the presence of fungal elements by KOH examination and culture on Sabouraud’s dextrose agar. Identification of fungal isolate was done by growth characteristics, LPCB wet mount, and slide culture. Result: During the study period, a total of 214 samples were received of which 17 (7.9%) were positive for fungal growth. Rhizopus arrhizus was most frequently isolated. Diabetes mellitus and the use of steroid during COVID-19 hospitalization was observed to be common risk factors. Rhino-cerebral mucormycosis was found to be the commonest type. Conclusion: Invasive mould infections can lead to fatal outcomes, if not detected timely. Accurate identification of the fungus is important for the administration of appropriate antifungal therapy.
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