基于纳米孔DNA测序的快速电流传感前端集成电路设计

2022 IEEE 16th International Conference on Anti-counterfeiting, Security, and Identification (ASID) Pub Date : 2022-12-02 DOI:10.1109/ASID56930.2022.9995851

Xu Liu, Qiumeng Fan, Xin Hu, Peiyuan Wan, Zhijie Chen

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引用次数: 0

摘要

提出了一种用于纳米孔DNA测序的快速传感前端集成电路。单链DNA穿过细胞膜上的纳米孔，在电极上产生超小电流。因此，本工作设计并优化了反阻抗放大器和电压-时间转换电路，实现了电流检测。该前端IC将单碱基检测时间至少减少到$\mathbf{10}\ \boldsymbol{\mu}\mathbf{s}$。整个电路采用180nm CMOS工艺实现。结果表明，所实现的集成电路可以检测10 pA的最小电流，并可以测量10 ~ 150 pA的纳米孔电流。它的功耗是$\mathbf{42}。\mathbf{8}\ \boldsymbol{\mu}\mathbf{W}$，输入级的输入参考噪声为1.93 pV2/Hz。

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A Fast Current Sensing Front-End IC Design for Nanopore-Based DNA Sequencing

This paper presents a fast sensing front-end integrated circuit for nanopore-based DNA sequencing. Single-stranded DNA passes through the nanopore on the cell membrane to generate an ultra-small current on the electrodes. Therefore, a trans-impedance amplifier and a voltage-to-time conversion circuit are designed and optimized in this work to realize the current detection. This front-end IC reduces the single base detection time to $\mathbf{10}\ \boldsymbol{\mu}\mathbf{s}$ at minimum. The whole circuit is implemented in 180-nm CMOS process. The results show that the implemented IC can detect the minimum current of 10 pA and can measure the current through nanopores ranging from 10 pA to 150 pA. Its power consumption is $\mathbf{42}.\mathbf{8}\ \boldsymbol{\mu}\mathbf{W}$, and the input reference noise of the input stage is 1.93 pV2/Hz.

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来源期刊

2022 IEEE 16th International Conference on Anti-counterfeiting, Security, and Identification (ASID)

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