Coronavirus Disease (COVID-19) Infection and Innate ImmunoResponse: Pathway to Eradicating the Pandemic

Covid-19 infection is highly transmissible with high degree of hospitalization and few level of lethality which has raised great concerns globally. Covid-19 is acquired through exposure to microdroplets present in exhalates of individuals already infected or by surface contact with contaminated formites with the viral particle and once the viral particle reaches the bronchioles and alveolar spaces; it binds to cells of the bronchial epithelium and Angiotensin 2 Converting Enzyme (ACE2) of the alveolar. An immense understanding of the interaction between Covid-19 infection and the host immune system could be the breakpoint needed to provide better management, treatment and support for the disease sufferers. Therefore, review of current knowledge between Covid-19 infection and the host innate immune system is important in order to sufficiently understand its pathogenesis and further give clues for the clinical management and development of preventive therapeutic strategies in treating this infection.