{"title":"血液BMP6与认知表现和阿尔茨海默病诊断相关:一项老年人的纵向研究。","authors":"Lin Sun, Chunni Guo, Yan Song, J. Sheng, S. Xiao","doi":"10.3233/jad-220279","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nBone morphogenetic protein (BMP) plays important roles in the pathology of Alzheimer's disease (AD).\n\n\nOBJECTIVE\nWe sought blood BMP6 involved in the processes underlying cognitive decline and detected them in association with AD.\n\n\nMETHODS\nA total of 309 participants in Shanghai Mental Health Center (SMHC) and 547 participants in Alzheimer's disease Neuroimaging Initiative (ADNI) cohort were included. Blood BMP6 and cognitive functions were measured in all subjects of both cohorts at baseline, and in 482 subjects of ADNI cohort after one year. A total of 300 subjects in ADNI cohort were detected cerebrospinal fluid (CSF) tau biomarker, and 244 received 1-year follow-up.\n\n\nRESULTS\nAD patients had lower levels of blood BMP6 compared to normal controls, and BMP6 was positively associated with cognitive functions. Longitudinal BMP6 combing with APOE genotype could distinguish probable AD from normal controls. The influence of blood BMP6 on cognition was modulated by tau pathology.\n\n\nCONCLUSION\nBlood BMP6 was associated with cognitive performance and identified as a potential predictor for probable AD.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"30 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.\",\"authors\":\"Lin Sun, Chunni Guo, Yan Song, J. Sheng, S. Xiao\",\"doi\":\"10.3233/jad-220279\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nBone morphogenetic protein (BMP) plays important roles in the pathology of Alzheimer's disease (AD).\\n\\n\\nOBJECTIVE\\nWe sought blood BMP6 involved in the processes underlying cognitive decline and detected them in association with AD.\\n\\n\\nMETHODS\\nA total of 309 participants in Shanghai Mental Health Center (SMHC) and 547 participants in Alzheimer's disease Neuroimaging Initiative (ADNI) cohort were included. Blood BMP6 and cognitive functions were measured in all subjects of both cohorts at baseline, and in 482 subjects of ADNI cohort after one year. A total of 300 subjects in ADNI cohort were detected cerebrospinal fluid (CSF) tau biomarker, and 244 received 1-year follow-up.\\n\\n\\nRESULTS\\nAD patients had lower levels of blood BMP6 compared to normal controls, and BMP6 was positively associated with cognitive functions. Longitudinal BMP6 combing with APOE genotype could distinguish probable AD from normal controls. The influence of blood BMP6 on cognition was modulated by tau pathology.\\n\\n\\nCONCLUSION\\nBlood BMP6 was associated with cognitive performance and identified as a potential predictor for probable AD.\",\"PeriodicalId\":219895,\"journal\":{\"name\":\"Journal of Alzheimer's disease : JAD\",\"volume\":\"30 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease : JAD\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/jad-220279\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease : JAD","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/jad-220279","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.
BACKGROUND
Bone morphogenetic protein (BMP) plays important roles in the pathology of Alzheimer's disease (AD).
OBJECTIVE
We sought blood BMP6 involved in the processes underlying cognitive decline and detected them in association with AD.
METHODS
A total of 309 participants in Shanghai Mental Health Center (SMHC) and 547 participants in Alzheimer's disease Neuroimaging Initiative (ADNI) cohort were included. Blood BMP6 and cognitive functions were measured in all subjects of both cohorts at baseline, and in 482 subjects of ADNI cohort after one year. A total of 300 subjects in ADNI cohort were detected cerebrospinal fluid (CSF) tau biomarker, and 244 received 1-year follow-up.
RESULTS
AD patients had lower levels of blood BMP6 compared to normal controls, and BMP6 was positively associated with cognitive functions. Longitudinal BMP6 combing with APOE genotype could distinguish probable AD from normal controls. The influence of blood BMP6 on cognition was modulated by tau pathology.
CONCLUSION
Blood BMP6 was associated with cognitive performance and identified as a potential predictor for probable AD.
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