Antibiotic Resistance, the Horrendous Consequences of Bacterial Sex

This chapter reviews how bacterial sex explains the rapid emergence of superbugs that are resistant to multiple antibiotics, the so-called MDR pathogens. Millions of years before humans evolved, bacteria invented antibiotics and the defensive molecules that make some bacteria resistant to an antibiotic. Therefore, antibiotic resistant genes pre-exist in many bacterial strains, literally lying in wait to emerge in superbugs. In postwar Japan, bacteriologists discovered the first MDR pathogens during dysentery outbreaks. Researchers demonstrated that the genes for resistance to several antibiotics were transferred by bacterial sex—from normal flora to the dysentery pathogens—all together and “at one stroke.” Methicillin was intentionally designed to treat penicillin-resistant infections. Only three years after its introduction of, hospitals began to find methicillin-resistant Staphylococcus aureus (MRSA). Gerard Wright coined the term resistome to signify “the global collection of resistance genes that have been readily available to pathogens for millennia.”