门静脉直径超声诊断食管静脉曲张的无创预测指标。

Amal Basnet, J. Thapa, K. Sapkota, A. Kc
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引用次数: 0

摘要

食道静脉曲张是肝病患者门静脉高压最严重的后果之一,如果不及时发现或不及时治疗,可导致上消化道大量出血,甚至可能致命。因此,及时发现和处理肝硬化患者的静脉曲张是必须的。一些研究已经评估了可能的食管静脉曲张的无创标记物,以减少肝硬化但无静脉曲张患者不必要的内窥镜检查次数。肝硬化患者食管静脉曲张的内镜监测对卫生系统来说是昂贵的,对患者来说是不舒服的。最近,基于非侵入性超声的参数似乎提供了关于食管静脉曲张状态的有价值的信息,从而挑战了重复内镜监测的需要。在这项研究中,我们的目的是建立一个预测模型,使用一个独立的风险因素来预测入组患者静脉曲张的存在。这是一项横断面研究。该研究分析了2014年2月至2015年1月期间的50例肝脏疾病患者。除肝细胞癌患者和既往因门静脉高压症进行手术或药物干预的患者外,所有肝硬化患者(不论性别)均被纳入研究。所有病例均行腹部超声检查门静脉直径。内镜下对静脉曲张进行分级。数据录入采用SPSS version 20,统计分析采用卡方检验。共有50名患者参加了这项试验。47例(96%)患者存在静脉曲张。13例(26%)患者存在小静脉曲张,34例(68%)患者存在大静脉曲张。小静脉曲张患者门静脉平均直径为13.23 mm,大静脉曲张患者门静脉平均直径为16.83 mm。以上结果说明静脉曲张的存在与门静脉平均内径13.23 mm及以上相关,p值为0.024,具有统计学意义,超声测量门静脉内径可作为门脉高压患者胃食管静脉曲张发展的无创预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Portal Vein Diameter by Ultrasonography as a non-Invasive Predictor of Esophageal Varices.
Esophageal varices are one of the most serious consequence of portal hypertension in patients with liver diseases If undetected or left untreated, it can result in massive upper gastrointestinal bleed and can be fatal. Therefore, a timely detection and management of the varices in cirrhotic patient is a must. Several studies have evaluated possible noninvasive  markers of esophageal varices to reduce the number of unnecessary endoscopies in patients with cirrhosis but without  varices. Endoscopic surveillance of esophageal varices in patients with liver cirrhosis is expensive for the health system  and uncomfortable for the patients. Recently, non-invasive ultrasound-based parameters seem to offer valuable information  about the status of esophageal varices and thus challenge the need for repetitive endoscopic monitoring. In this study, our  aim was to develop a predictive model using an independent risk factor for the presence of varices in the enrolled patients. This is a cross-sectional study. The study analyzed 50 patients with liver diseases from February 2014 to January 2015. All the patients with cirrhosis of either gender except those with hepatocellular carcinoma and previous surgical or medical  intervention for portal hypertension were enrolled in the study. Ultrasound of the abdomen was done in all cases to note  the portal vein diameter. The varices visualized were graded endoscopically. Data entry was done in SPSS version 20 and statistical analysis was done with Chi Square test. Total 50 patients were enrolled in the test. Varices was present in 47  (96%) of the patients. Small varices were present in 13 (26%) and large varices was present in 34 (68%) of patients. For  the patients with small varices, the mean portal vein diameter was 13.23 mm and for those with large varices, the mean  portal vein diameter was 16.83 mm. The above results signify that the presence of varices was associated with the mean portal vein diameter of 13.23 mm or more and the result was statistically significant with the p value of 0.024 Measurement  of portal vein diameter by ultrasonography can be used as a non-invasive predictive indicator of the development of gastro- esophageal varices in patients with portal hypertension.
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