红果油对铅暴露小鼠肝脏炎症的保护作用

Lina Aderia Putri, N. Ningtyas, Alfiana Laili Dwi Agustin
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引用次数: 0

摘要

背景:环境污染日益严重,铅锤就是其中之一。已知暴露于铅会诱导活性氧(ROS)的过量产生并导致细胞水平的氧化应激。氧化应激会引起身体器官的紊乱,其中之一就是肝脏。目的:探讨红果油对小鼠肝脏炎症细胞水平铅暴露的保护作用。方法:本研究共进行14天,分为4个处理,分别为P0(阴性对照)、P1(阳性对照,0.011mg剂量铅暴露)、P2 (0.011mg剂量红果油和铅暴露0.3 ml)和P3 (0.011mg剂量红果油和铅暴露0.8 ml)。通过在400倍放大镜下观察小鼠肝脏HE制剂来测定小鼠肝脏中的炎症细胞。结果:根据结果,P1、P2、P3处理经SPSS检验无显著性差异。结论:应用红果油对铅暴露小鼠的炎症细胞水平无影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective Effect of Red Fruit Oil (Pandanus conoideus Lam.) on Histopathological Levels of Liver Inflammation in Mice (Mus musculus) Exposed to Lead
Background: There is an increase in pollution in the environment, and plumb is one of them. Exposure to plumbum is known to induce excessive production of Reactive Oxygen Species (ROS) and result in oxidative stress at the cellular level. Oxidative stress can cause disturbances in body organs, one of which is the liver organ. Purpose: To determine the effect of giving red fruit oil as protection against plumbum exposure at the level of inflammatory cells of the mice’s liver. Method: This study was conducted for 14 days with 4 treatments, namely P0 (negative control), P1 (positive control given plumbum exposure at a dose of 0.011mg), P2 (0.3 ml of red fruit oil and plumbum exposure at a dose of 0.011mg) and P3 (0.8 ml of red fruit oil and plumbum exposure at a dose of 0.011mg). Determination of inflammatory cells in the liver of mice is carried out by looking at the HE preparation of mice’s liver under a microscope with a magnification of 400x. Results: Based on the results, it was found that there was no noticeable difference after the SPSS test on the P1, P2, and P3 treatments. Conclusion: The application of red fruit oil as a protectant to mice exposed to plumbum does not affect the level of inflammatory cells.
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