{"title":"尼日利亚2型糖尿病患者胰岛素抵抗的评价","authors":"N. Oranye, P. Anaja, A. Bakari","doi":"10.15640/ijmp.v7n1a3","DOIUrl":null,"url":null,"abstract":"Background: The link between Insulin Resistance (IR) and type 2 Diabetes Mellitus (T2DM) has been well recognized for well over half a century. Not only is it the most powerful predictor of future development of type 2 diabetes mellitus, it is also a therapeutic target once hyperglycaemia is present. The current study seeks to evaluate Insulin Resistance in type 2 Diabetic subjects and proffer a reference range for insulin resistance in the ABUTH, Zaria area. Materials and Methods: Serum insulin resistance, insulin, lipids, fasting plasma glucose, glycated haemoglobin and anthropometric parameters were measured in 180 type 2 diabetic and 180 control subjects. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) method. Serum insulin was measured using the ELISA method while spectrophotometric methods were used for blood glucose, glycated haemoglobin and serum lipids. The results were analysed statistically using the two-tailed student’s t-test and the one way analysis of variance (ANOVA). Results: Mean serum insulin resistance levels were significantly higher in the type 2 diabetic group than in the control group (P < 0.05). Mean FPG, HBA1C and serum insulin levels were also significantly higher in the diabetic group than in the control group (P < 0.05). Mean TC, LDL-C and TC/HDL-C levels were higher but not significantly in the diabetics than in the controls (P > 0.05). Mean TG level was significantly higher in the diabetic group than in the control group (P < 0.05) while mean HDL-C level was nonsignificantly lower in the diabetic group than in the control group (P > 0.05). Mean values for anthropometric parameters (BMI and SBP) were significantly higher in the type 2 diabetic subjects than in the control subjects (P < 0.05) while mean DBP was higher in the diabetic group but not significantly (P > 0.05). A significant positive correlation was observed between insulin resistance and insulin (r = 0.817, P < 0.000), FPG (r = 0.560, P < 0.000) and HBA1c (r = 0.275, P < 0.000) in the entire study, but only with FPG (r =0.482, P <0.000) and insulin (r = 0.803, P < 0.000) in the diabetic group. The results of the current study show an increased insulin resistance level in type 2 diabetic subjects compared to the control group and reference range for insulin resistance was obtained as 0.51 – 2.27. Conclusion In view of the importance of insulin resistance as a powerful predictor of future T2DM, a periodic measurement of insulin resistance is suggested for all.","PeriodicalId":422929,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICINE AND PHARMACY","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Insulin Resistance in Type 2 Diabetic Nigerians\",\"authors\":\"N. Oranye, P. Anaja, A. Bakari\",\"doi\":\"10.15640/ijmp.v7n1a3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The link between Insulin Resistance (IR) and type 2 Diabetes Mellitus (T2DM) has been well recognized for well over half a century. Not only is it the most powerful predictor of future development of type 2 diabetes mellitus, it is also a therapeutic target once hyperglycaemia is present. The current study seeks to evaluate Insulin Resistance in type 2 Diabetic subjects and proffer a reference range for insulin resistance in the ABUTH, Zaria area. Materials and Methods: Serum insulin resistance, insulin, lipids, fasting plasma glucose, glycated haemoglobin and anthropometric parameters were measured in 180 type 2 diabetic and 180 control subjects. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) method. Serum insulin was measured using the ELISA method while spectrophotometric methods were used for blood glucose, glycated haemoglobin and serum lipids. The results were analysed statistically using the two-tailed student’s t-test and the one way analysis of variance (ANOVA). Results: Mean serum insulin resistance levels were significantly higher in the type 2 diabetic group than in the control group (P < 0.05). Mean FPG, HBA1C and serum insulin levels were also significantly higher in the diabetic group than in the control group (P < 0.05). Mean TC, LDL-C and TC/HDL-C levels were higher but not significantly in the diabetics than in the controls (P > 0.05). Mean TG level was significantly higher in the diabetic group than in the control group (P < 0.05) while mean HDL-C level was nonsignificantly lower in the diabetic group than in the control group (P > 0.05). Mean values for anthropometric parameters (BMI and SBP) were significantly higher in the type 2 diabetic subjects than in the control subjects (P < 0.05) while mean DBP was higher in the diabetic group but not significantly (P > 0.05). A significant positive correlation was observed between insulin resistance and insulin (r = 0.817, P < 0.000), FPG (r = 0.560, P < 0.000) and HBA1c (r = 0.275, P < 0.000) in the entire study, but only with FPG (r =0.482, P <0.000) and insulin (r = 0.803, P < 0.000) in the diabetic group. The results of the current study show an increased insulin resistance level in type 2 diabetic subjects compared to the control group and reference range for insulin resistance was obtained as 0.51 – 2.27. Conclusion In view of the importance of insulin resistance as a powerful predictor of future T2DM, a periodic measurement of insulin resistance is suggested for all.\",\"PeriodicalId\":422929,\"journal\":{\"name\":\"INTERNATIONAL JOURNAL OF MEDICINE AND PHARMACY\",\"volume\":\"36 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"INTERNATIONAL JOURNAL OF MEDICINE AND PHARMACY\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15640/ijmp.v7n1a3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"INTERNATIONAL JOURNAL OF MEDICINE AND PHARMACY","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15640/ijmp.v7n1a3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:胰岛素抵抗(IR)和2型糖尿病(T2DM)之间的联系已经被公认了半个多世纪。它不仅是2型糖尿病未来发展的最有力的预测指标,而且一旦出现高血糖,它也是一个治疗靶点。目前的研究旨在评估2型糖尿病受试者的胰岛素抵抗,并为ABUTH, Zaria地区的胰岛素抵抗提供参考范围。材料与方法:测定180例2型糖尿病患者和180例对照者的血清胰岛素抵抗、胰岛素、血脂、空腹血糖、糖化血红蛋白及人体测量参数。采用稳态模型评估(HOMA)方法计算胰岛素抵抗。采用ELISA法测定血清胰岛素,分光光度法测定血糖、糖化血红蛋白和血脂。采用双尾学生t检验和单因素方差分析(ANOVA)对结果进行统计分析。结果:2型糖尿病患者血清胰岛素抵抗水平显著高于对照组(P < 0.05)。糖尿病组平均FPG、HBA1C、血清胰岛素水平均显著高于对照组(P < 0.05)。糖尿病组TC、LDL-C、TC/HDL-C水平均高于对照组,但差异无统计学意义(P > 0.05)。糖尿病组平均TG水平显著高于对照组(P < 0.05),平均HDL-C水平显著低于对照组(P > 0.05)。2型糖尿病组的BMI和收缩压平均值显著高于对照组(P < 0.05),糖尿病组的舒张压平均值高于对照组(P > 0.05)。在整个研究中,胰岛素抵抗与胰岛素(r = 0.817, P <0.000)、FPG (r = 0.560, P <0.000)、HBA1c (r = 0.275, P <0.000)呈正相关,但在糖尿病组中仅与FPG (r =0.482, P <0.000)和胰岛素(r = 0.803, P <0.000)呈正相关。本研究结果显示,与对照组相比,2型糖尿病患者胰岛素抵抗水平升高,胰岛素抵抗参考范围为0.51 - 2.27。结论鉴于胰岛素抵抗是预测未来T2DM的重要指标,建议对所有患者进行胰岛素抵抗的定期检测。
Evaluation of Insulin Resistance in Type 2 Diabetic Nigerians
Background: The link between Insulin Resistance (IR) and type 2 Diabetes Mellitus (T2DM) has been well recognized for well over half a century. Not only is it the most powerful predictor of future development of type 2 diabetes mellitus, it is also a therapeutic target once hyperglycaemia is present. The current study seeks to evaluate Insulin Resistance in type 2 Diabetic subjects and proffer a reference range for insulin resistance in the ABUTH, Zaria area. Materials and Methods: Serum insulin resistance, insulin, lipids, fasting plasma glucose, glycated haemoglobin and anthropometric parameters were measured in 180 type 2 diabetic and 180 control subjects. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) method. Serum insulin was measured using the ELISA method while spectrophotometric methods were used for blood glucose, glycated haemoglobin and serum lipids. The results were analysed statistically using the two-tailed student’s t-test and the one way analysis of variance (ANOVA). Results: Mean serum insulin resistance levels were significantly higher in the type 2 diabetic group than in the control group (P < 0.05). Mean FPG, HBA1C and serum insulin levels were also significantly higher in the diabetic group than in the control group (P < 0.05). Mean TC, LDL-C and TC/HDL-C levels were higher but not significantly in the diabetics than in the controls (P > 0.05). Mean TG level was significantly higher in the diabetic group than in the control group (P < 0.05) while mean HDL-C level was nonsignificantly lower in the diabetic group than in the control group (P > 0.05). Mean values for anthropometric parameters (BMI and SBP) were significantly higher in the type 2 diabetic subjects than in the control subjects (P < 0.05) while mean DBP was higher in the diabetic group but not significantly (P > 0.05). A significant positive correlation was observed between insulin resistance and insulin (r = 0.817, P < 0.000), FPG (r = 0.560, P < 0.000) and HBA1c (r = 0.275, P < 0.000) in the entire study, but only with FPG (r =0.482, P <0.000) and insulin (r = 0.803, P < 0.000) in the diabetic group. The results of the current study show an increased insulin resistance level in type 2 diabetic subjects compared to the control group and reference range for insulin resistance was obtained as 0.51 – 2.27. Conclusion In view of the importance of insulin resistance as a powerful predictor of future T2DM, a periodic measurement of insulin resistance is suggested for all.