[修饰过的细菌核糖核酸酶的抗病毒作用]。

Nauchnye doklady vysshei shkoly. Biologicheskie nauki Pub Date : 1992-01-01

M K Indulen, N A Zamiatina, V P Varlamov, A V Il'ina

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引用次数: 0

摘要

研究了细菌核糖核酸酶与堪察加蟹壳聚糖(以水溶性壳寡糖的形式)偶联物的抗病毒活性。在组织培养中显示了对A和B病毒以及Sindbis虫媒病毒的结合抑制活性。在实验性流感感染小鼠中观察了该制剂的肌内和鼻内给药效果。

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[The antiviral action of a modified bacterial ribonuclease].

The antiviral activity of a bacterial ribonuclease conjugate with chitosane of Kamchatka crab (in a form of water soluble chito-oligosaccharides) has been studied. The conjugate inhibitory activity for A and B viruses as well as to Sindbis arbovirus in tissue cultures is shown. The preparation efficiency at intramuscular and intranasal administration was observed at experimental influenza infection of white mice.

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Nauchnye doklady vysshei shkoly. Biologicheskie nauki

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