一例22岁女性病例:静脉-静脉体外膜氧合

C. .
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摘要

体外膜氧合(Extracorporeal membrane oxygenation)是医学科学的伟大创新之一,在各种肺衰竭的情况下,难以维持身体的氧合,以支持人类的生命。ECMO被认为是传统体外循环技术的一个很好的选择,并在20世纪70年代发展成为严重急性呼吸窘迫综合征(ARDS)的治疗方法。在一个类似的主题上已经进行了许多种研究。最初关于在ARDS患者中应用ECMO的报道是非常令人兴奋的,后来,ECMO被证明对患有急性呼吸衰竭的婴儿肯定是有利的,生存率几乎达到80%。1979年至1994年期间,有两项大型随机对照试验在成年ARDS患者中进行,结果显示ECMO失败,ECMO组的存活率在10%至33%之间。从那时起,通过结合肺保护性通气策略和应用肝素包被设备、膜和导管,对ARDS患者的ECMO治疗取得了进一步的进展。许多医疗机构已经使用了这种先进的体外膜氧合技术,并实现了50%以上的存活率。然而,改良后的ECMO能否真正挑战成人ARDS的先进常规治疗仍存在争议,需要进一步研究。可见急性呼吸衰竭需要重症监护。在少数情况下,呼吸机支持不证明有效,只有选择V-V ECMO。本文描述的情况下,22岁的女性患者谁是入院的严重急性呼吸窘迫综合征,并伴有多器官衰竭。该患者因疑似病因不明的急性肾损伤而被送往富通医院急诊。在病房进行最初的4天诊断后,患者需要再住院治疗24天,并在重症监护室度过16天。在那里,她接受了ECMO V-V治疗,持续14天,最初动脉血气参数和临床情况有所改善,但后来出现气胸,病情日益恶化,逐渐危重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A 22 Year Old Female Case Scenario: Veno-venous Extracorporeal Membrane Oxygenation
ECMO (Extracorporeal membrane oxygenation) is one of the epic innovations of medical science to support the life of a human, in various conditions of lung failure, where it is difficult to maintain oxygenation of the body. ECMO was considered a very good option for conventional cardiopulmonary bypass technique and evolved into treatment of severe acute respiratory distress syndrome (ARDS) during the 1970s. Many kinds of research have been done on a similar topic. The initial reports on the utilisation of ECMO in ARDS patients were very exciting, and afterwards, ECMO proved to be certainly advantageous in infants having acute respiratory failure with a survival rate of almost 80%. There were two large randomised controlled trials, done during the period of 1979-1994 in adults with ARDS, that showed the failure of ECMO, with the survival rate range between 10% to 33%in the ECMO groups. Since then, ECMO treatment for ARDS patients has undergone further advancements by combining with lung-protective ventilation strategies and further by applying heparin-coated equipment, membranes, and tubings. Many healthcare facilities have used this advanced ECMO technology and achieved survival rates of more than 50%. However, whether improved ECMO can really challenge the advanced conventional treatment of adult ARDS is still a matter of debate and needs further studies.It was seen that acute respiratory failure requires intensive care. In few cases where ventilator support doesn’t prove effective, only the option of V-V ECMO remains. The present article describes the case of a 22-year-old female patient who was admitted with severe acute respiratory distress syndrome with associated multiple organ failure. The patient was admitted to the emergency of the Fortis Hospital with suspected acute kidney injury of unknown aetiology. After the initial 4 days of diagnostics at the ward, the patient required a further 24 days of hospital treatment and spent 16 days at the Intensive Care Unit. There, she underwent ECMO V-V therapy, lasting 14 days, which resulted initially in the improvement of his arterial blood gas parameters and clinical condition but later on, she developed pneumothorax and her condition worsened day by day gradually becoming critical.
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