肿瘤定位对皮肤黑色素瘤患者晚期诊断和治疗的影响分析

D. Lukic, P. Lazić, Jadran Milos Bandic, Đ. Radak, N. Babić, D. Ivić
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摘要

前瞻性研究比较2004年6月至2012年6月肿瘤部位对皮肤黑色素瘤晚期诊断和治疗的影响。根据临床表现分为两组。第一组,A组(32名应答者)由在疾病早期接受原发肿瘤根治性广泛切除的应答者组成。在第二组中,B组(32名应答者)被分类为在疾病后期接受根治性黑色素瘤切除术的黑色素瘤应答者。本研究的目的是分析肿瘤定位对皮肤黑色素瘤晚期诊断和治疗的影响。早期手术的25例(78.1%)患者黑色素瘤位于面部、胸部、腹部和四肢,7例(21.9%)患者黑色素瘤位于背部。晚期手术组9例(28.1%)黑色素瘤位于面部、胸部、腹部和四肢,23例(71.9%)肿瘤位于背部。研究表明,肿瘤定位本质上决定了受访者就诊的时间。背部黑色素瘤较长时间未被发现,即与其他解剖区域的病变相比,病变发生了未被识别的变化,这可能是造成时间浪费更大、诊断较晚的原因。B组受访者咨询医生4-5个月后,因为黑色素瘤的位置比A组,这被证明具有统计学意义。在疾病复发率方面发现了统计学上的显著差异。B组复发率是a组的3倍。黑色素瘤的定位显著影响疾病的治疗结果。分组应答者的存活率在统计学上有显著差异,因为B组的死亡率几乎是B组的三倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The analysis of influence of tumor localization on late diagnosis and treatment in patients with skin melanoma
With the prospective study, from June 2004 to June 2012, were compared the results of the influence of tumor position on late diagnosis and treatment of skin melanoma. Respondents were classified according to clinical appearance in 2 equal groups. The first group, group A (32 respondents) consisted of respondents that underwent radical wide excision of the primary tumor at an early stage of the disease. In the second group, group B (32 respondents) were classified respondents with melanoma that underwent radical excision of melanoma at a later stage of the disease. The aim of this study was to analyze the influence of tumor localization on late diagnosis and treatment of skin melanoma. In 25 respondents (78.1%) who were operated at an early stage, melanoma was located on the face, chest, abdomen and extremities, while in 7 (21.9%) respondents, melanoma was localized on the back. In the group of late operated respondents, melanoma was positioned on the face, chest, abdomen and extremities in 9 (28.1%) respondents, while in 23 (71.9%) respondents, tumor was localized on the back. It has been shown that tumor localization essentially determines the time of visits of respondents for examination. Melanoma on the back remains unnoticed for a long time, i.e. unrecognized changes in lesions compared to lesions of other anatomical regions, which is probably the reason for the bigger waste of time and late diagnosis. Respondents in group B consulted the doctor 4-5 months later, because of melanoma position than the group A, which is proved to be statistically significant. There was found a statistically significant difference in terms of recurrence of the disease. Relapse was observed in group B 3 times higher than in group A. Localization of melanoma significantly affects the outcome of the treatment of the disease. There was a statistically significant difference in survival of respondents in groups, because the mortality rate in group B was almost three times higher.
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