l -精氨酸在心血管系统中的作用

E. Sudar-Milovanovic, M. Obradović, V. Bajic, Nikola Bogdanović, Đ. Radak, E. Isenovic
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引用次数: 0

摘要

必需氨基酸l -精氨酸(L-Arg)在心血管系统中起着重要作用。文献资料显示,L-Arg是产生一氧化氮(NO)的唯一底物,一氧化氮是L-Arg对心血管系统的作用的基础。NO是一种自由基,由l -精氨酸合成,具有NO合成酶(NOS)活性。在高血压、糖尿病、高胆固醇血症和血管炎症状态下,l -精氨酸合成NO的代谢途径发生紊乱,这些代谢途径共同导致血管的改变。临床研究表明,l -精氨酸对血小板、凝血过程和纤溶系统有影响。本文综述的所有新数据表明,l -精氨酸可能是改善心血管疾病的重要治疗分子之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of L-Arginine in cardiovascular system
The essential amino acid, L-Arginine (L-Arg) has an important role in the cardiovascular system. Literature data show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammal cells by L-Arg with the activity of NO synthase (NOS). In the states of hypertension, diabetes, hypercholesterolemia and vascular inflammation, a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations to blood vessels. Clinical studies show that L-Arg has an effect on thrombocytes, the process of coagulation and the fibrolytic system. All the new data summarized in this review suggest that L-Arg could be one of important therapeutic molecules for improving cardiovascular disorders.
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