Urinary Tract Infection In Children With Acute Nephritic Syndrome.

Fifty-four of the 63 cases of acute nephrotic syndrome (ANS) paediatric wards of the University of Benin Teaching Hospital, Benin City, over a 5 year period were prospectively evaluated for prevalence of Urinary Tract Infection (UTI). Of the 54,26 (48.1%) were males while 28 (51.9%) were females. The mean age (+SEM) of the children was 6.9+0.50 years (Range 0.90-15 years). Forty-nine (90.1%) of these children with ANS were drawn from families of low socio-economic status. Prevalence of UTI was 24.1%. Although UTI prevalence in families (32.1%) was higher than in males (15.4%), The difference was not statistically significant ( xy2=2.14: p>0.05). The prevalence of UTI amongst these patients was remarkably higher than what is observed both in healthy childhood population and those with other association morbidities. Escherichia coli (61.5%) Klebsiella pneumoniae (15.4%) and Staphylococcus aureus (23.1%) were the bacterial isolates that demonstrated appreciable in-vitro sensitivity to ofloxacin, gentamycin, ceftriazone, ceftazidime and azithromycin only. Some interaction may exist between UTI and ANS but further studies are advocated in other centers to evaluate the observation. And access possible association between degree of proeinmia and prevalence of UTI. Annals of Biomedical Science Vol. 1 (1) 2002: pp. 22-29