蛋白质-蛋白质相互作用网络中非必需-非枢纽蛋白的拓扑特征

2012 3rd International Conference on System Science, Engineering Design and Manufacturing Informatization Pub Date : 2012-11-12 DOI:10.1109/ICSSEM.2012.6340764

Yun-yuan Dong, Yang Jun, Qi-jun Liu, Zheng-hua Wang

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引用次数: 0

摘要

在蛋白质-蛋白质相互作用(PPI)网络中，发现蛋白质的拓扑特性与功能特征之间的关系是系统生物学的一个重要问题。在PPI网络中有许多必需的非枢纽蛋白和许多非必需的非枢纽蛋白。必要的非枢纽蛋白和非必要的非枢纽蛋白都是低连接蛋白，但它们具有不同的致命性。为了解释为什么非必需的非枢纽蛋白不是必需的，我们从拓扑学的角度将它们与必需的非枢纽蛋白进行比较。比较结果表明，非必需-非枢纽蛋白与必需-非枢纽蛋白在中心性度量和聚类系数上存在统计学差异。

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The topological features of nonessential-nonhub proteins in the protein-protein interaction network

One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.

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2012 3rd International Conference on System Science, Engineering Design and Manufacturing Informatization

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