保加利亚5岁以下儿童急性呼吸道感染的病因学结构

I. Trifonova, S. Angelova, N. Korsun
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引用次数: 1

摘要

急性呼吸道感染(ARI)是婴幼儿发病和住院的主要原因。本研究旨在确定保加利亚5岁以下儿童ARI的病毒病原学和最常见呼吸道病毒的临床意义。在2017年10月至2019年3月期间,从不同国家地区收集了5岁以下儿童的鼻咽标本。实时荧光定量PCR检测流感病毒A/B、呼吸道合胞病毒(RSV)、人偏肺病毒(HMPV)、副流感病毒(PIV) 1型、2型和3型、鼻病毒(RV)、腺病毒(AdV)和bocavavirus (BoV)。在接受检查的953名儿童中,663名(69.6%)至少对一种病毒呈阳性。A(H1N1)pdm09、A(H3N2)、B/Yamagata、B/Victoria、RSV、HMPV、PIV-1、PIV-2、PIV-3、RV、AdV、HBoV共检出150株(15.7%)、51株(5.6%)、50株(5.2%)、1株(0.1%)、193株(20.3%)、38株(4%)、15株(1.6%)、5株(0.5%)、17株(1.8%)、101株(10.6%)、60株(6.3%)、77株(8.1%)。95名(14.3%)感染儿童同时感染两种或三种病毒。AdV、RV、BoV和PIV-3是合并感染中最常见的病原体。喉气管炎、细支气管炎、肺炎及中枢神经系统并发症患儿呼吸道病毒检出率分别为80%、79.3%、61.2%和53.1%。结果显示,在研究期间,呼吸道合胞病毒、流感病毒、RV和BoV是5岁以下急性呼吸道感染儿童中检出最多的病毒。这些病毒也是呼吸道和中枢神经系统严重疾病的主要病原体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AETIOLOGICAL STRUCTURE OF ACUTE RESPIRATORY TRACT INFECTIONS AMONG CHILDREN YOUNGER THAN 5 YEARS IN BULGARIA
Acute respiratory tract infections (ARI) are a leading cause of morbidity and hospital admissions among infants and young children. This study aims to determine the viral aetiology of ARI and the clinical significance of the most common respiratory viruses in children aged <5 years in Bulgaria. During the period October 2017-March 2019, nasopharyngeal specimens were collected from children younger than 5 years in different country regions. Real-time PCR analysis was performed for detection of influenza viruses A/B, respiratory-syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza viruses (PIV) types 1, 2 and 3, rhinoviruses (RV), adenoviruses (AdV) and bocaviruses (BoV). Of the 953 children examined, 663 (69.6%) were positive for at least one virus. The number of detected A(H1N1)pdm09, A(H3N2), B/Yamagata, B/Victoria, RSV, HMPV, PIV-1, PIV-2, PIV-3, RV, AdV and HBoV viruses was as follows: 150 (15.7%), 51 (5.6%), 50 (5.2%), 1 (0.1%), 193 (20.3%), 38 (4%), 15 (1.6%), 5 (0.5%), 17 (1.8%), 101 (10.6%), 60 (6.3%), 77 (8.1%), respectively. Co-infections with two and three viruses were found in 95 (14.3%) of the infected children. AdV, RV, BoV and PIV-3 were the most common pathogens in co-infections. Respiratory viruses were detected in 80%, 79.3%, 61.2% and 53.1% of children with laryngotracheitis, bronchiolitis, pneumonia and central nervous system (CNS) complications. The results show that RSV, influenza viruses, RV and BoV were the most frequently detected viruses in children <5 years with ARI during the study period. These viruses were also leading causative agents of serious illnesses of the respiratory tract and CNS.
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