MORPHOFUNCTIONAL ASPECTS OF AGING THAT DETERMINE THE COURSE OF RESPIRATORY DISEASES IN OLD AND SENILE AGE

Aim. Based on an analysis of the medical literature, describe the key features of age-related organic and functional changes that potentially affect the course and therapy of respiratory diseases in elderly and senile people. Material and methods. A review of publications in the scientific and methodological literature on the problems of physiological and pathological aging, the epidemiology of somatic pathology and the peculiarities of its clinical manifestations and outcomes in the age aspect, including the relationship with the course of non-infectious and infectious respiratory diseases in elderly and senile people, is carried out. Results and discussion. The article provides relevant data on morbidity and mortality from respiratory pathology in old and senile age. A description is given of the mechanisms of aging of organs and systems, changes in the regulation of their functions, including changes in immunoreactivity from the standpoint of influence on the occurrence and course of respiratory diseases. Conclusion. When managing elderly and senile patients, it is necessary to take into account the age-related characteristics of the aging organism, the existing comorbid pathology and its therapy, take a differentiated approach to the assessment of the clinic, taking into account the direct signs of age-associated symptoms and manifestations of the «pharmacological cascade».