生物功能化和示踪剂交联在磁粒子光谱中的作用

2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI:10.1109/IWMPI.2013.6528378

H. Arami, R. M. Ferguson, A. Khandhar, A. Tomitaka, K. Krishnan

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引用次数: 2

摘要

在本文中，我们提出了一种配体交换和聚乙二醇化的方法，用于开发单分散的MPI示踪剂(核心尺寸~ 20nm)，其表面具有所需的活性-NH2和/或-SH官能团。首先，通过硅烷化反应将游离羧基引入NPs表面。然后，用碳二亚胺试剂(DCC)将NH2-PEG-NH2或NH2-PEG-SH分子的胺基与这些羧基结合。

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Role of biofunctionalization and tracer cross-linking in magnetic particle spectrometry

In this paper, we present a ligand exchange and PEGylation approach for developing monodisperse MPI tracers (core size ~ 20nm) with the required reactive -NH2 and/or -SH functional groups on their surface. First, free carboxyl groups were introduced on the surface of the NPs through a silanization reaction. Then, a carbodiimide reagent (DCC) was used to bond the amine groups of the NH2-PEG-NH2 or NH2-PEG-SH molecules to these carboxyl groups.

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2013 International Workshop on Magnetic Particle Imaging (IWMPI)

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