填充剂对维生素C的产生质量的影响

Desy Nawangsari
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引用次数: 2

摘要

Avicel®PH是微晶纤维素的品牌名称,通常用于药物制剂。Avicel®PH被用作片剂配方中的填料或粘合剂,特别是用于直接压缩,因为它具有良好的流动速率和良好的可压缩性。本研究旨在比较Avicel®PH 101和Avicel®PH 102作为填料对抗坏血酸片剂制剂的影响。采用不同填料制备抗坏血酸片颗粒剂,并对颗粒剂进行了评价。结果表明,Avicel®ph102作为填料制备的抗坏血酸片颗粒剂从流动性、静息角、卡尔指数和豪斯纳比等方面都能较好地反映出抗坏血酸片颗粒剂的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C
Avicel® PH is branded name from microcrystalline cellulose that is generally used in pharmaceutical preparations. Avicel® PH are being used as filler or binder in dosage formulas in tablets especially for direct compression because having a good flowing rate and a good compressibility. This study aims to compare the influence of the use Avicel® PH 101 and Avicel® PH 102 as a filler on of preparations a tablet of ascorbic acid. A method of the research was conducted by making granule of ascorbic acid tablet with the variation filler, then the granule was evaluate in .The results showed Avicel® PH 102 as a filler produce granule which better seen from the flowability, static angle of repose, carr’s index and hausner ratio .  
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