不同研究模式下早期产后刺激对产前应激的衰减作用

A. Liaudat, Nora Mayer, A. Vivas, M. C. Romanini, P. Bosch, Nancy Rodríguez
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引用次数: 2

摘要

在哺乳动物的发育过程中,产前和产后早期都是动态和脆弱的阶段。暴露于干扰这一关键事件序列的不利因素中,使受暴露者在成年生活中患各种疾病的风险更高。1-3例如,妊娠应激的雌性动物穿过胎盘和胎儿血脑屏障时,高血糖皮质激素浓度会影响后代的大脑发育、出生体重和HPA轴功能
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Attenuation effects of prenatal stress by early postnatal stimulation in different research models
The prenatal and early postnatal life stages are both dynamic and vulnerable phases during mammalian development. Exposure to adverse factors that interfere with this critical sequence of events places the exposed individual to a higher risk of developing various disorders in adult life.1–3 For instance, high blood glucocorticoids concentration in pregnant stressed females crossing the placenta and the fetal blood-brain barriers,4 can affect brain development, birth weight and HPA axis function in offspring.5
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