R. Karba, D. Matko, B. Zupančič, A. Mrhar, S. Primozic, P. Kozjek
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Usage of analog-hybrid and digital simulation in pharmacokinetics
The possibility of combining analog-hybrid computers and digital simulation languages in all phases of pharmacokinetic model development, evaluation, and usage is discussed. The pharmacokinetic study of ciprofloxacin illustrates the application of an EAI-2000 analog parallel processor and the digital simulation language SIMCOS. Conclusions concerning simulation tools for pharmacokinetic models are presented.<>