β失败-cellulare在1型和2型糖尿病:有共同机制吗?

Il Diabete Pub Date : 2022-07-11 DOI:10.30682/ildia2202g
Nicola Marrano, G. Biondi, F. Giorgino, A. Natalicchio
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引用次数: 0

摘要

1型糖尿病(T1D)和2型糖尿病(T2D)是两种不同的疾病,具有不同的病因和发病机制,但有一个共同的结局(高血糖),分别由β细胞功能团几乎完全或减少的损失引起。虽然导致β细胞衰竭的原因不同(T1D通常是免疫介导的,而T2D则与代谢应激有关),但两种糖尿病的潜在分子途径几乎相似。在这篇综述中,我们试图强调在T1D和T2D中β-细胞损伤的共同分子机制,这可能会提出新的有希望的共同治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fallimento β-cellulare nel diabete mellito di tipo 1 e di tipo 2: esistono meccanismi comuni?
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are two distinct diseases, with different etiology and pathogenesis, but with a common outcome (hyperglycemia), caused by almost complete or reduced loss of β-cell functional mass, respectively. Although the causes that lead to β-cell failure are different (typically immune-mediated for T1D, while related to metabolic stress for T2D), the underlying molecular pathways are almost sim¬ilar in both forms of diabetes. In this review we try to highlight common molecular mechanisms of β-cells damage in T1D and T2D, which could suggest new promising common therapeutic targets.
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