恩多昔芬治疗双相情感障碍伴共病性物质使用障碍两例报告

M. Dave, N. Shanmugasundaram
{"title":"恩多昔芬治疗双相情感障碍伴共病性物质使用障碍两例报告","authors":"M. Dave, N. Shanmugasundaram","doi":"10.25259/abp_1_2023","DOIUrl":null,"url":null,"abstract":"Bipolar disorder (BI) is a common occurrence and increases the risk of substance use disorder. This comorbidity has potentially serious consequences including suicide attempts, hospitalization, and rapid cycling. Endoxifen could play a role in the management of BI based on the inhibition of protein kinase C, which also has a role in substance abuse. We present two cases of patients with bipolar mania and comorbid substance use disorder, who were effectively and safely treated with adjunct Endoxifen. The addition of Endoxifen addition reduced manic symptoms as well as substance use. Furthermore, the inclusion of Endoxifen permitted the use of lower doses of other drugs in one patient and reduced the pill burden in the other patient. Endoxifen has the potential for use in the management of BI in patients with comorbid substance abuse.","PeriodicalId":361830,"journal":{"name":"Archives of Biological Psychiatry","volume":"229 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endoxifen for the management of bipolar disorder with comorbid substance use disorder: A report of two cases\",\"authors\":\"M. Dave, N. Shanmugasundaram\",\"doi\":\"10.25259/abp_1_2023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bipolar disorder (BI) is a common occurrence and increases the risk of substance use disorder. This comorbidity has potentially serious consequences including suicide attempts, hospitalization, and rapid cycling. Endoxifen could play a role in the management of BI based on the inhibition of protein kinase C, which also has a role in substance abuse. We present two cases of patients with bipolar mania and comorbid substance use disorder, who were effectively and safely treated with adjunct Endoxifen. The addition of Endoxifen addition reduced manic symptoms as well as substance use. Furthermore, the inclusion of Endoxifen permitted the use of lower doses of other drugs in one patient and reduced the pill burden in the other patient. Endoxifen has the potential for use in the management of BI in patients with comorbid substance abuse.\",\"PeriodicalId\":361830,\"journal\":{\"name\":\"Archives of Biological Psychiatry\",\"volume\":\"229 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Biological Psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25259/abp_1_2023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Biological Psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25259/abp_1_2023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

双相情感障碍(BI)是一种常见的现象,并增加了物质使用障碍的风险。这种合并症具有潜在的严重后果,包括自杀企图、住院治疗和快速循环。Endoxifen可能在抑制蛋白激酶C的基础上对BI的管理起作用,这也在药物滥用中起作用。我们提出了两例双相躁狂症和共病物质使用障碍患者,他们有效和安全的治疗辅助恩多昔芬。恩多昔芬的加入减少了躁狂症状和药物使用。此外,纳入Endoxifen允许在一名患者中使用较低剂量的其他药物,并减少了另一名患者的药丸负担。恩多昔芬有可能用于治疗合并药物滥用的BI患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endoxifen for the management of bipolar disorder with comorbid substance use disorder: A report of two cases
Bipolar disorder (BI) is a common occurrence and increases the risk of substance use disorder. This comorbidity has potentially serious consequences including suicide attempts, hospitalization, and rapid cycling. Endoxifen could play a role in the management of BI based on the inhibition of protein kinase C, which also has a role in substance abuse. We present two cases of patients with bipolar mania and comorbid substance use disorder, who were effectively and safely treated with adjunct Endoxifen. The addition of Endoxifen addition reduced manic symptoms as well as substance use. Furthermore, the inclusion of Endoxifen permitted the use of lower doses of other drugs in one patient and reduced the pill burden in the other patient. Endoxifen has the potential for use in the management of BI in patients with comorbid substance abuse.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信