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LLM Dergi Pub Date : 2020-12-15 DOI:10.5578/LLM.20219903

E. Atilla, Pınar Ataca Atilla, Sinem Civriz Bozdağ, Meltem Kurt Yüksel, S. Toprak, Önder Arslan, Meral Beksaç, Muhit Özcan, Günhan Gürman, Pervin Topçuoğlu

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摘要

目的:原发性移植失败被定义为供体细胞没有移植或血液学恢复的证据，而继发性移植失败是指先前功能的移植物的丧失。我们的目的是介绍原发性和继发性移植物失败的病例，包括人口统计学特征、治疗方法和结果。患者和方法:自1992年以来，我们的回顾性研究纳入了13例在我们中心诊断为移植失败而进行第二次HSCT的患者(11例原发性/2例继发性)。评估患者的特征、生存和治疗方法。结果:本组患者年龄中位数29岁(16 ~ 64岁)，其中男性9例。11例患者原发性移植物衰竭诊断如下:骨髓衰竭综合征(再生障碍性贫血(AA)、范可尼再生障碍性贫血(FAA)、骨髓增生异常综合征(MDS) 8例，急性髓性白血病(AML) 2例，慢性髓性白血病(CML) 1例。二次移植失败中检测出1 ErdenİLLA1İD Pınar ATACA在İLLA1İD, Sinem CİVRİZ BOZDAĞ1İD, Meltem KURT YUKSEL1İD, Selami Kocak TOPRAK1İD,出席ARSLAN1İD, Meral BEKSAC1İD, Muhit OZCAN1İD, Gunhan GURMAN1İD, Pervin TOPCUOĞLU1İD 1安卡拉Universitesi TıP Fakultesi Hematoloji Bilim Dalı,安卡拉Turkiye Erden在İLLA安卡拉Universitesi TıP Fakultesi Hematoloji Bilim DalıAnkara-Turkiye Geliş:22.02.2021喀布尔:24.02.2021 E-posta:erdenatilla@gmail.com Yazışma Adresi ARAŞTIRMA LLM Dergi 2020;4(4):65-70•10.5578/ LLM .20219903Makale atıfı: Atilla E, Ataca Atilla P, Civriz bozdauls, Kurt y ksel M, Toprak SK, Arslan Ö ve ark。Allojeneik kök h cre naklinde引物ve接枝yetmezliği。法学学报，2020;4(4):65-70。

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Allojeneik Kök Hücre Naklinde Primer ve Sekonder Graft Yetmezliği

Objective: Primary Engraftment Failure is defined as no evidence of engraftment or hematological recovery of donor cells whereas secondary graft failure refers to the loss of a previously functioning graft. Our aim is to present our cases of primary and secondary graft failure in terms of demographical features, treatments and outcomes. Patients and Methods: From 1992, 13 patients who had second HSCT for graft failure (11 primary/2 secondary) diagnosed at our center were included in our retrospective study. The patient characteristics, survival and therapeutic approaches were evaluated. Results: The median age of the group was 29 (range, 16-64), 9 of them were male. 11 patients had primary graft failure diagnosed as follows: 8 bone marrow failure syndromes (aplastic anemia (AA), fanconi aplastic anemia (FAA), myelodysplastic syndrome (MDS), 2 acute myeloid leukemia (AML), 1 chronic myeloid leukemia (CML). Secondary graft failure was detected in 1 Erden ATİLLA1 İD , Pınar ATACA ATİLLA1 İD , Sinem CİVRİZ BOZDAĞ1 İD , Meltem KURT YÜKSEL1 İD , Selami Koçak TOPRAK1 İD , Önder ARSLAN1 İD , Meral BEKSAÇ1 İD , Muhit ÖZCAN1 İD , Günhan GÜRMAN1 İD , Pervin TOPÇUOĞLU1 İD 1 Ankara Üniversitesi Tıp Fakültesi, Hematoloji Bilim Dalı, Ankara, Türkiye Erden ATİLLA Ankara Üniversitesi Tıp Fakültesi, Hematoloji Bilim Dalı, Ankara-Türkiye Geliş: 22.02.2021 Kabul: 24.02.2021 E-posta: erdenatilla@gmail.com Yazışma Adresi ARAŞTIRMA LLM Dergi 2020;4(4):65-70 • 10.5578/llm.20219903 Makale atıfı: Atilla E, Ataca Atilla P, Civriz Bozdağ S, Kurt Yüksel M, Toprak SK, Arslan Ö ve ark. Allojeneik kök hücre naklinde primer ve sekonder graft yetmezliği. LLM Dergi 2020;4(4):65-70.

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LLM Dergi

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