前列腺癌患者在雄激素剥夺治疗下血清尿素、肌酐和电解质的评估

S. Elhassan, Y. Suliman, G. Modawe
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引用次数: 0

摘要

背景:前列腺癌是男性生殖系统最常见的癌症,死亡率高,雄激素剥夺治疗(ADT)是侵袭性和晚期前列腺癌治疗的关键组成部分。目的:探讨前列腺癌ADT患者在测定血清电解质(Na、K)的同时,血清尿素和肌酐的变化。方法:喀土穆州喀土穆肿瘤医院接受(ADT)治疗的100名苏丹前列腺癌(PCa)患者。该研究于2018年4月和7月进行。PCa患者的年龄在50 ~ 73岁之间,平均年龄为62.2岁。从每个病人身上抽取血样。用分光光度计法测定尿素和肌酐,用火焰光度计法测定血清电解质。结果:血清尿素、肌酐、Na、K的均值±SD分别为(41.31±27.6mg/dl、1.26±0.93mg/dl、141.37±11.52mg/dl、4.38±3.89mg/dl)。血清尿素、肌酐、钠、钾均在正常范围内。ADT治疗前列腺癌患者血清尿素差异有统计学意义(P=0.000),尿素与肌酐、Na与k之间存在显著相关性。结论:本研究认为ADT治疗对前列腺癌患者血肾参数无影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Serum Urea, Creatinine, and electrolytes in Patients with Prostate Cancer under Androgen Deprivation Therapy
Background: Prostate cancer is the most common cancer in a male of the reproductive system and associated with high mortality and Androgen-deprivation therapy (ADT) is a key component of treatment for aggressive and advanced prostate cancer. Objective: The aim of this study was to assess the serum urea and creatinine beside the measure of serum electrolytes (Na and K) in patients with prostate cancer under (ADT).Methodology: 100 Sudanese patients with prostate cancer (PCa) under (ADT) attended in Khartoum oncology hospital, Khartoum state. The study conducted in April and July 2018. The age of PCa patients ranged between (50 to73 years) and their mean 62.2 years. The blood samples were taken from each patient. The urea and creatinine were estimated using spectrophotometer methods and also the serum electrolytes were measured by using flame photometers methods. Results: The (mean±SD) of serum urea, creatinine, Na and K were (41.31±27.6mg/dl,1.26±0.93mg/dl,141.37±11.52mg/dl,4.38±3.89mg/dl) respectively. The concentration of serum urea, creatinine, Na and K were normal within a normal range. There was significantly (P=0.000) difference of serum urea among prostate cancer patients under ADT and there was a significant correlation between urea and creatinine and also between Na and K. Conclusion: In this study concluded that the ADT  has no effect on blood renal parameters among prostate cancer.
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