生物信息学信息资源整合:信息集群管理

S. Ram, Rohit Kumar Sureka, P. Sharma, N. Laxman Rao
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引用次数: 1

摘要

人类基因组计划于2003年完成,由美国国立卫生研究院(NIH)和美国能源部共同承担,确定构成脱氧核糖核酸(DNA)的化学碱基对序列。这个大型项目产生了大量的数据和信息。通过全基因组测序、微阵列技术、单核苷酸多态性(snp)、蛋白质组学和许多其他努力产生的大量数据,为大多数传统训练的生物学家创造了如何解释和利用丰富信息的知识鸿沟。数据的存储、管理和处理也对信息科学家提出了挑战,从而产生了生物信息学。生物信息学这门学科从生物科学、计算机科学、遗传学、数学和统计学等各个学科领域汲取概念。各种相关资源也以出版的文献、专门的生物信息学中心、生物特定数据库和分析数据的软件工具的形式出现。数据库驱动技术作为维护和维持信息的解决方案之一而出现。生物信息学是一个新兴的学科领域,它采用多维的方法来分析数据。由于生物信息的异质性,在生物信息的产生、传播和相互作用方面存在着各种各样的问题。生物信息学信息的使用者往往发现获得相关信息的认识和获取是一项挑战。信息素养、建立数据库、整合信息资源并以有帮助的方式呈现信息资源,是增强信息获取的一些解决方案。这篇论文是关于设计和开发一个单一的工具,以提供访问各种生物信息学资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating bioinformatics information resources: Management of information through clustering
Human Genome Project completed in 2003 undertaken by National Institute of Health (NIH), USA and US Department of Energy to determine the sequence of chemical base pair which make up Deoxyribonucleic Acid (DNA). This mega project generated huge amount of Data and Information. The Enormous amount of data generated through whole-genome sequencing efforts, microarray technologies, and mapping of single nucleotide polymorphisms (SNPs), proteomics, and many other efforts, have created chasm of knowledge for most traditionally trained biologists on how to interpret and utilize wealth of information. The storage and management of the data and its processing posed challenges to the information scientists too, which resulted in the birth of bioinformatics. The discipline, Bioinformatics is drawing concepts from various subject areas such as biological sciences, computer science, genetics, mathematics and statistics. Various related resources also emerged in the form of published literature, specialized centers for bioinformatics, organism specific databases and software tools to analyze data. Database driven technology emerged as one of the solution to maintain and sustain the information. Bioinformatics being a novice subject field and it utilizes multidimensional approach for analysis of data. There are various problems related to generation, communication and interaction of biological information due to heterogeneity. The Users of bioinformatics information often find it a challenge to get awareness and access to the relevant information. Information literacy, creation of databases, consolidation of information resources and presenting them in helpful manner for coherent access are some of solutions for enhanced access. This paper is deals with design and development of a single tool for providing access to variety of resources in bioinformatics.
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