热可调注射型热敏水凝胶及其作为蛋白质载体的应用

Pengfei Xie, Lifang You, Yahao Ma, Tianyin Chen, Xiaoying Wang
{"title":"热可调注射型热敏水凝胶及其作为蛋白质载体的应用","authors":"Pengfei Xie, Lifang You, Yahao Ma, Tianyin Chen, Xiaoying Wang","doi":"10.54097/ijbls.v3i2.10088","DOIUrl":null,"url":null,"abstract":"It is known that polymer chemistries determine mechanical and physical properties of hydrogels and thus its drug delivery performance. In order to achieve desired drug release behavior, triblock copolyester PCT-PEG-PCT with proper hydrogel formulation has to be synthesized. This research has demonstrated a way to adjust hydrogel mechanical and gelation properties by simply physically mixing amphiphilic copolymers with different composition to achieve desired protein carriers. Tri-block copolymer poly (CL-co-TOSUO)-PEG-poly (CL-co-TOSUO), briefed as (PCT-PEG-PCT) with different composition have been successfully synthesized. These copolymers are thermosensitive and can form hydrogels in aqueous solution. Copolymers with higher percentage hydrophobic PCT blocks show higher mechanical stiffness and yet lower solubility. To reduce the crystallinity of the hydrophobic block and soften the hydrogel, the copolymer with long PCT blocks was physically mixed with ones with shorter PCT blocks. The polymer mixture demonstrated a moderated mechanical stiffness and desired solubility. The polymer mixture also achieved a gelation temperature at 37°C, which is desirable for drug delivery. Macromolecular drug, bovine serum albumin (BSA) was used as model drug for its release study. This protein drug was successfully loaded into the polymer mixture, and the drug release study shows the polymer mixture is able to extend a stable drug release for over 48 hours. This result confirms physical mixing of PCT-PET-PCT thermosensitive copolymers can tune gel properties and improve drug delivery performance without redesigning and synthesizing new polymers.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"134 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thermo-tunable Injectable Thermosensitive Hydrogel and its Application as Protein Carriers\",\"authors\":\"Pengfei Xie, Lifang You, Yahao Ma, Tianyin Chen, Xiaoying Wang\",\"doi\":\"10.54097/ijbls.v3i2.10088\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It is known that polymer chemistries determine mechanical and physical properties of hydrogels and thus its drug delivery performance. In order to achieve desired drug release behavior, triblock copolyester PCT-PEG-PCT with proper hydrogel formulation has to be synthesized. This research has demonstrated a way to adjust hydrogel mechanical and gelation properties by simply physically mixing amphiphilic copolymers with different composition to achieve desired protein carriers. Tri-block copolymer poly (CL-co-TOSUO)-PEG-poly (CL-co-TOSUO), briefed as (PCT-PEG-PCT) with different composition have been successfully synthesized. These copolymers are thermosensitive and can form hydrogels in aqueous solution. Copolymers with higher percentage hydrophobic PCT blocks show higher mechanical stiffness and yet lower solubility. To reduce the crystallinity of the hydrophobic block and soften the hydrogel, the copolymer with long PCT blocks was physically mixed with ones with shorter PCT blocks. The polymer mixture demonstrated a moderated mechanical stiffness and desired solubility. The polymer mixture also achieved a gelation temperature at 37°C, which is desirable for drug delivery. Macromolecular drug, bovine serum albumin (BSA) was used as model drug for its release study. This protein drug was successfully loaded into the polymer mixture, and the drug release study shows the polymer mixture is able to extend a stable drug release for over 48 hours. This result confirms physical mixing of PCT-PET-PCT thermosensitive copolymers can tune gel properties and improve drug delivery performance without redesigning and synthesizing new polymers.\",\"PeriodicalId\":182292,\"journal\":{\"name\":\"International Journal of Biology and Life Sciences\",\"volume\":\"134 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biology and Life Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54097/ijbls.v3i2.10088\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biology and Life Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54097/ijbls.v3i2.10088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

众所周知,聚合物化学决定了水凝胶的机械和物理性质,从而决定了其给药性能。为了达到预期的药物释放行为,必须合成具有合适水凝胶配方的三嵌段共聚聚酯PCT-PEG-PCT。这项研究展示了一种通过简单地物理混合不同组成的两亲共聚物来调节水凝胶机械和凝胶性能的方法,以获得所需的蛋白质载体。成功合成了不同组成的三嵌段共聚物(CL-co-TOSUO)-聚乙二醇(CL-co-TOSUO),简称为(PCT-PEG-PCT)。这些共聚物具有热敏性,可在水溶液中形成水凝胶。具有较高百分比疏水性PCT嵌段的共聚物具有较高的机械刚度和较低的溶解度。为了降低疏水嵌段的结晶度,软化水凝胶,将长PCT嵌段的共聚物与短PCT嵌段的共聚物物理混合。聚合物混合物表现出适度的机械刚度和所需的溶解度。聚合物混合物也达到37℃的凝胶温度,这是药物递送所需要的。以大分子药物牛血清白蛋白(BSA)为模型药物进行释放研究。这种蛋白质药物被成功地装载到聚合物混合物中,药物释放研究表明,聚合物混合物能够延长药物稳定释放超过48小时。这一结果证实了PCT-PET-PCT热敏共聚物的物理混合可以调整凝胶性质并改善药物传递性能,而无需重新设计和合成新的聚合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thermo-tunable Injectable Thermosensitive Hydrogel and its Application as Protein Carriers
It is known that polymer chemistries determine mechanical and physical properties of hydrogels and thus its drug delivery performance. In order to achieve desired drug release behavior, triblock copolyester PCT-PEG-PCT with proper hydrogel formulation has to be synthesized. This research has demonstrated a way to adjust hydrogel mechanical and gelation properties by simply physically mixing amphiphilic copolymers with different composition to achieve desired protein carriers. Tri-block copolymer poly (CL-co-TOSUO)-PEG-poly (CL-co-TOSUO), briefed as (PCT-PEG-PCT) with different composition have been successfully synthesized. These copolymers are thermosensitive and can form hydrogels in aqueous solution. Copolymers with higher percentage hydrophobic PCT blocks show higher mechanical stiffness and yet lower solubility. To reduce the crystallinity of the hydrophobic block and soften the hydrogel, the copolymer with long PCT blocks was physically mixed with ones with shorter PCT blocks. The polymer mixture demonstrated a moderated mechanical stiffness and desired solubility. The polymer mixture also achieved a gelation temperature at 37°C, which is desirable for drug delivery. Macromolecular drug, bovine serum albumin (BSA) was used as model drug for its release study. This protein drug was successfully loaded into the polymer mixture, and the drug release study shows the polymer mixture is able to extend a stable drug release for over 48 hours. This result confirms physical mixing of PCT-PET-PCT thermosensitive copolymers can tune gel properties and improve drug delivery performance without redesigning and synthesizing new polymers.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信