Female Adnexal Tumors of Probable Wolffian Origin (FATWO); Challenges and Diagnostic Clues on Intra-operative Frozen Section Diagnosis

Female adnexal tumors of probable Wolffian origin (FATWO) or Wolffian adnexal tumors (WAT) are rare neoplasms that arise from the remnants of the mesonephric duct. The tumor is usually benign but can histologically look similar to some other malignant tumors. FATWO is characterized by diffuse and tubular patterns. The intra-operative diagnosis of FATWO is challenging because of the tumor’s rarity and its morphologic overlap with these other entities, and FATWO should be considered in the differential diagnoses of sex-cord stromal tumors and ovarian carcinomas based on the exclusion of other neoplasms. The case was presented at College of American Pathologists (CAP) annual conference in Florida (September 2019), and the abstract was published in Archives as an online supplement only.