THE SCIENTIFICS DISCUSSION OF WORLDWIDE CHALLENGES OF COVID-19 PANDEMIC AND GENERAL DRUG THERAPY APPROACHES TO COMBAT THE COVID-19 DISEASES

A new type of coronavirus (COVID-19) SARS-CoV-2 originated in Wuhan, China and has caused a global pandemic. COVID-19 is a newly emerging infectious disease caused by SARS-CoV-2 and is known as SARS. By July 1, 2020, more than 10 million people worldwide will be infected with SARS-CoV-2. Typical manifestations of COVID-19 are fever, sore throat, fatigue, cough, and shortness of breath combined with recent exposure. Most COVID-19 patients have mild to moderate illness; however, 5 to 10% have a serious and even life-threatening illness. The death rate is around 2-3%. Therefore, there was an urgent need for a specific and effective antiviral treatment. Supportive measures such as oxygenated ventilation and fluid handling remain the standard of care today. Several clinical studies are ongoing to determine the most effective drug or combination for this disease and it is highly recommended that patients be included in ongoing studies. The safety and effectiveness of antiviral drugs could only be demonstrated in randomized clinical trials. Several active ingredients such as chloroquine, hydroxychloroquine, favipiravir, monoclonal antibodies, antisense RNA, corticosteroids, convalescent plasma and vaccines were currently being evaluated. A variety of therapeutic interventions were aimed at determining the most effective regimen. The purpose of this article is to describe the treatment strategies that have been used for patients with COVID-19 and to review all available literature. Keywords: Worldwide, therapy, treatment, COVID-19 diseases, pandemic.