Muhammad Imran Khan, Hafiz M.N. Iqbal, Y. Garedaghi, M. Bilal
{"title":"丙型肝炎病毒感染的分子流行病学——现状与展望","authors":"Muhammad Imran Khan, Hafiz M.N. Iqbal, Y. Garedaghi, M. Bilal","doi":"10.34172/ijmpes.2021.19","DOIUrl":null,"url":null,"abstract":"Hepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than 71 million people (which equals to almost 1% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at 31%-33% of nucleotides. Each genotype is further classified into several subtypes. Collectively, 86 subtypes have been recognized which differ from each other at<15% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness programs via extended approaches can prove useful in controlling the prevalence of HCV as well as other infectious diseases.","PeriodicalId":189386,"journal":{"name":"International Journal of Medical Parasitology and Epidemiology Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular Epidemiology of Hepatitis C Virus Infection― Status Quo and outlook\",\"authors\":\"Muhammad Imran Khan, Hafiz M.N. Iqbal, Y. Garedaghi, M. Bilal\",\"doi\":\"10.34172/ijmpes.2021.19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than 71 million people (which equals to almost 1% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at 31%-33% of nucleotides. Each genotype is further classified into several subtypes. Collectively, 86 subtypes have been recognized which differ from each other at<15% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness programs via extended approaches can prove useful in controlling the prevalence of HCV as well as other infectious diseases.\",\"PeriodicalId\":189386,\"journal\":{\"name\":\"International Journal of Medical Parasitology and Epidemiology Sciences\",\"volume\":\"34 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Medical Parasitology and Epidemiology Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/ijmpes.2021.19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Parasitology and Epidemiology Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/ijmpes.2021.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular Epidemiology of Hepatitis C Virus Infection― Status Quo and outlook
Hepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than 71 million people (which equals to almost 1% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at 31%-33% of nucleotides. Each genotype is further classified into several subtypes. Collectively, 86 subtypes have been recognized which differ from each other at<15% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness programs via extended approaches can prove useful in controlling the prevalence of HCV as well as other infectious diseases.