利用磁凝胶珠的旋转运动快速释放药物

T. Mitsumata, Yusuke Kakiuchi, J. Takimoto
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引用次数: 7

摘要

通过磁凝胶珠的快速旋转,实现了药物的加速释放。磁性凝胶珠由氯化钙交联的海藻酸钠组成,其中含有铁磁性颗粒的钡铁氧体,以及作为药物的酮洛芬。磁珠在旋转磁场的作用下进行旋转运动。在不旋转的情况下,药物释放到磷酸盐缓冲溶液中的量服从非菲克扩散。在25分钟时,药物的自发释放量达到了0.90 mg的饱和值,相当于完全释放量的92%。随着转速的增加,药物释放速度加快。达到完美释放的最短时间约为3分钟,相当于1/8的情况下不旋转。在快速释放的同时,可能是由于水头周围的强水流导致水头坍塌。高弹性微珠不易塌陷,且无快速释放现象。因此,酮洛芬的快速释放是由微珠的崩塌触发的。介绍了微珠崩塌的照片,药物释放的时间分布,以及磁场调制的脉冲释放。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fast Drug Release Using Rotational Motion of Magnetic Gel Beads
Accelerated drug release has been achieved by means of the fast rotation of magnetic gel beads. The magnetic gel bead consists of sodium alginate crosslinked by calcium chlorides, which contains barium ferrite of ferrimagnetic particles, and ketoprofen as a drug. The bead underwent rotational motion in response to rotational magnetic fields. In the case of bead without rotation, the amount of drug release into a phosphate buffer solution obeyed non-Fickian diffusion. The spontaneous drug release reached a saturation value of 0.90 mg at 25 minutes, which corresponds to 92% of the perfect release. The drug release was accelerated with increasing the rotation speed. The shortest time achieving the perfect release was approximately 3 minutes, which corresponds to 1/8 of the case without rotation. Simultaneous with the fast release, the bead collapsed probably due to the strong water flow surrounding the bead. The beads with high elasticity were hard to collapse and the fast release was not observed. Hence, the fast release of ketoprofen is triggered by the collapse of beads. Photographs of the collapse of beads, time profiles of the drug release, and a pulsatile release modulated by magnetic fields were presented.
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