槭心材红景天苷的镇痛和抗胃病作用

Y. Yoo, Jung‐Hwan Nam, Min-Young Kim, Jong-Won Choi, Kyung-Tae Lee, Hee-Juhn Park
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引用次数: 13

摘要

红枫(槭树科)的心材被用作治疗酒精中毒和肝炎的韩国传统药物。为了寻找毛蕊花心材的生物活性物质,我们研究了毛蕊花心材提取物及其成分对小鼠疼痛和胃病的保护作用。在这些实验中,红景天苷,一种主要化合物,显著减轻了小鼠胃损伤和疼痛。口服红景天苷10和20 mg/kg剂量可显著降低盐酸/乙醇(抑制作用分别为51.5%和68.8%)和吲哚美辛/麻酚(抑制作用分别为31.3%和38.8%)引起的胃损伤。红景天苷还能稳定胃液pH值,增加胃液分泌和总酸输出。综上所述,这些结果表明红柳苷是毛蕊草心材的主要成分,可以预防饮酒引起的胃损伤和疼痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analgesic and Anti-Gastropathic Effects of Salidroside Isolated from Acer tegmentosum Heartwood
The heartwood of Acer tegmentosum (Acereaceae) has been used as a Korean traditional medicinal drug against alcohol poisoning and hepatitis. To find the biologically active substance in A. tegmentosum heartwood, we investigated the protective effects of the heartwood extract and its constituents on pain and gastropathy in mouse. In these experiments, salidroside, a major compound, significantly reduced gastric lesion and pain in mice. Oral administration of salidroside at the 10 and 20 mg/kg doses greatly reduced the gastric lesion induced by HCl/ethanol (inhibitory effect, 51.5 and 68.8%, respectively) and by indomethacin/bethanechol (inhibitory effect, 31.3 and 38.8%, respectively). Salidroside also stabi- lized pH of gastric juice and the increase of gastric juice secretion and total acid output. Taken together, these results demonstrated that salidroside is the main ingredient of A. tegmentosum heartwood to prevent gastric lesion and pain that can be caused by drinking alcohol.
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