壳聚糖:一种良好的眼部缓释药物递送系统

L. Popa, M. Ghica, C. Dinu-Pîrvu, Teodora Irimia
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引用次数: 13

摘要

这一章的重点是眼睛,人类最重要的器官之一。目前有关人眼病理生理的数据与一系列治疗产品直接相关,其中包括一种众所周知且广泛使用的材料,即壳聚糖。介绍了壳聚糖生物聚合物在创新、现代、治疗设备和解决方案开发中的应用。因此,壳聚糖是一种很好的赋形剂,既适用于经典滴型眼系统,也适用于复杂的药物系统,如纳米结构(纳米颗粒、纳米胶束和纳米悬浮液)、脂质体、微乳液、微球、原位水凝胶和植入物或植入物。这样就克服了眼部给药的一些缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems
This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.
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