林同省产产金刚伞化合物的抗炎活性研究

Journal of Science and Technology Issue on Information and Communications Technology Pub Date : 2022-12-31 DOI:10.31130/ud-jst.2022.295e

To Dao Cuong To, N. D. Nguyen, Phi Hung Nguyen Phi, Nguyen Huu Kien Nguyen, Ngu Truong Nhan Ngu, Nguyen Thi Nguyen, Manh Hung Tran Manh

{"title":"林同省产产金刚伞化合物的抗炎活性研究","authors":"To Dao Cuong To, N. D. Nguyen, Phi Hung Nguyen Phi, Nguyen Huu Kien Nguyen, Ngu Truong Nhan Ngu, Nguyen Thi Nguyen, Manh Hung Tran Manh","doi":"10.31130/ud-jst.2022.295e","DOIUrl":null,"url":null,"abstract":"Five natural secondary metabolites as cinnamic acid (1), (+)-catechin (2), (-)-epicatechin (3), p-coumaric acid (4), and ferulic acid (5) were isolated from Amanita caesarea based on anti-inflammatory activity-guided extraction. Their structures (1-5) were determined by NMR spectra as well as by comparison with previously reported literature. Compounds 3 and 5 have been isolated from A. caesarea for the first time. The anti-inflammatory activity through inhibition of nitric oxide (NO) production of isolates (1-5) was evaluated. Among them, compounds 2 and 3 exhibited strong inhibitory activity with IC50 values of 4.8 and 5.7 μM, respectively. Compounds 4 and 5 with IC50 values of 18.4 and 9.6 μM, respectively showed moderate inhibitory activity. The results proposed that A. caesarea might exert anti-inflammatory effects due to its mainly NO-inhibitory constituents","PeriodicalId":262140,"journal":{"name":"Journal of Science and Technology Issue on Information and Communications Technology","volume":"159 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-inflammatory activities of compounds isolated from Amanita caesarea collected in Lam Dong province\",\"authors\":\"To Dao Cuong To, N. D. Nguyen, Phi Hung Nguyen Phi, Nguyen Huu Kien Nguyen, Ngu Truong Nhan Ngu, Nguyen Thi Nguyen, Manh Hung Tran Manh\",\"doi\":\"10.31130/ud-jst.2022.295e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Five natural secondary metabolites as cinnamic acid (1), (+)-catechin (2), (-)-epicatechin (3), p-coumaric acid (4), and ferulic acid (5) were isolated from Amanita caesarea based on anti-inflammatory activity-guided extraction. Their structures (1-5) were determined by NMR spectra as well as by comparison with previously reported literature. Compounds 3 and 5 have been isolated from A. caesarea for the first time. The anti-inflammatory activity through inhibition of nitric oxide (NO) production of isolates (1-5) was evaluated. Among them, compounds 2 and 3 exhibited strong inhibitory activity with IC50 values of 4.8 and 5.7 μM, respectively. Compounds 4 and 5 with IC50 values of 18.4 and 9.6 μM, respectively showed moderate inhibitory activity. The results proposed that A. caesarea might exert anti-inflammatory effects due to its mainly NO-inhibitory constituents\",\"PeriodicalId\":262140,\"journal\":{\"name\":\"Journal of Science and Technology Issue on Information and Communications Technology\",\"volume\":\"159 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Science and Technology Issue on Information and Communications Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31130/ud-jst.2022.295e\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Science and Technology Issue on Information and Communications Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31130/ud-jst.2022.295e","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

采用抗炎活性引导提取的方法，从该植物中分离到肉桂酸(1)、(+)-儿茶素(2)、(-)-表儿茶素(3)、对香豆酸(4)和阿魏酸(5)5种天然次生代谢产物。它们的结构(1-5)通过核磁共振谱以及与先前报道的文献的比较确定。化合物3和5为首次从该植物中分离得到。通过抑制一氧化氮(NO)的产生来评估其抗炎活性(1-5)。其中化合物2和3表现出较强的抑制活性，IC50值分别为4.8 μM和5.7 μM。化合物4和5的IC50值分别为18.4和9.6 μM，具有中等抑制活性。结果提示，该植物可能以no抑制成分为主，具有抗炎作用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Anti-inflammatory activities of compounds isolated from Amanita caesarea collected in Lam Dong province

Five natural secondary metabolites as cinnamic acid (1), (+)-catechin (2), (-)-epicatechin (3), p-coumaric acid (4), and ferulic acid (5) were isolated from Amanita caesarea based on anti-inflammatory activity-guided extraction. Their structures (1-5) were determined by NMR spectra as well as by comparison with previously reported literature. Compounds 3 and 5 have been isolated from A. caesarea for the first time. The anti-inflammatory activity through inhibition of nitric oxide (NO) production of isolates (1-5) was evaluated. Among them, compounds 2 and 3 exhibited strong inhibitory activity with IC50 values of 4.8 and 5.7 μM, respectively. Compounds 4 and 5 with IC50 values of 18.4 and 9.6 μM, respectively showed moderate inhibitory activity. The results proposed that A. caesarea might exert anti-inflammatory effects due to its mainly NO-inhibitory constituents

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Science and Technology Issue on Information and Communications Technology

自引率

0.00%

发文量