{"title":"基于MoS2/SnS2异质结构的蛋白质展开","authors":"Runyi Yuan, Wei Si","doi":"10.1109/3M-NANO56083.2022.9941518","DOIUrl":null,"url":null,"abstract":"In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved problems the unfolding of structured proteins into chain-like structures is a prerequisite for nanopore sequencing. In this work, we propose a general two-dimensional heterostructure that can be used for protein unfolding without the need for specific biological or chemical reagents. The role of two-dimensional heterostructures on protein unfolding is studied by molecular dynamics, which provides new inspiration for the subsequent experiments to achieve a general and reliable protein unfolding method.","PeriodicalId":370631,"journal":{"name":"2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protein Unfolding with MoS2/SnS2 Heterostructure\",\"authors\":\"Runyi Yuan, Wei Si\",\"doi\":\"10.1109/3M-NANO56083.2022.9941518\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved problems the unfolding of structured proteins into chain-like structures is a prerequisite for nanopore sequencing. In this work, we propose a general two-dimensional heterostructure that can be used for protein unfolding without the need for specific biological or chemical reagents. The role of two-dimensional heterostructures on protein unfolding is studied by molecular dynamics, which provides new inspiration for the subsequent experiments to achieve a general and reliable protein unfolding method.\",\"PeriodicalId\":370631,\"journal\":{\"name\":\"2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)\",\"volume\":\"37 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/3M-NANO56083.2022.9941518\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/3M-NANO56083.2022.9941518","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved problems the unfolding of structured proteins into chain-like structures is a prerequisite for nanopore sequencing. In this work, we propose a general two-dimensional heterostructure that can be used for protein unfolding without the need for specific biological or chemical reagents. The role of two-dimensional heterostructures on protein unfolding is studied by molecular dynamics, which provides new inspiration for the subsequent experiments to achieve a general and reliable protein unfolding method.